Role of pancreatic impairment in growth recovery during gluten-free diet in childhood celiac disease

Gastroenterology
Antonio CarroccioG Montalto

Abstract

Clinical significance and duration of insufficient release of pancreatic enzymes in childhood celiac disease have not been clarified. The aim of this study was to evaluate the role that pancreatic impairment plays in growth recovery and the duration of this impairment. Forty-six patients with celiac disease who had a median age of 2.5 years were enrolled. Fecal chymotrypsin level was determined at diagnosis and then every 15 days after the beginning of a gluten-free diet in all patients. At diagnosis, 17 of 46 patients with celiac disease had subnormal fecal chymotrypsin values. During the gluten-free diet, a progressive reduction in the percentage of patients with subnormal fecal chymotrypsin values was observed: 12 of 46 patients after 30 days and 2 of 46 patients after 60 days. Weight increase after 2 months of gluten-free diet was significantly greater in patients with normal fecal chymotrypsin values at diagnosis than in patients with subnormal values, and a positive correlation was found between fecal chymotrypsin at diagnosis and weight increase (r = 0.56). A small percentage of patients with celiac disease still had subnormal chymotrypsin concentrations after 60 days of gluten-free diet. Fecal chymotrypsin is a predicti...Continue Reading

Citations

Jan 25, 2002·Archives of Disease in Childhood·M G SchäppiK J Lindley
Aug 31, 1999·Scandinavian Journal of Gastroenterology·A CarroccioG Montalto
Nov 26, 1998·Scandinavian Journal of Gastroenterology·A PicarelliP Vernia
Aug 19, 2015·Journal of Clinical Gastroenterology·Elisa StasiGiovanni Monteleone
Aug 30, 2011·Primary Care·Zafreen Siddiqui, Amimi S Osayande
Jun 10, 2009·Best Practice & Research. Clinical Gastroenterology·Jutta KellerPeter Layer
Feb 3, 2007·Alimentary Pharmacology & Therapeutics·J S LeedsD S Sanders
May 12, 2009·Journal of Paediatrics and Child Health·Mohammed HasosahKevan Jacobson
May 31, 2006·Gastrointestinal Endoscopy·Sunil AryaDeepak Kumar Bhasin
Sep 21, 2001·European Journal of Gastroenterology & Hepatology·A CarroccioG Iacono
Nov 9, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A CarroccioG Iacono
Mar 13, 1998·Gastroenterology·J C GomezJ C Bai
Aug 23, 2002·The American Journal of Gastroenterology·Ahmad S AbdulkarimJoseph A Murray
Sep 21, 2001·Alimentary Pharmacology & Therapeutics·A CarroccioA Notarbartolo
Jun 9, 2001·Journal of Pediatric Gastroenterology and Nutrition·R ShamirG Dinari
May 12, 2010·Digestive Diseases and Sciences·Kate E EvansDavid S Sanders
Sep 7, 2006·Journal of Pediatric Gastroenterology and Nutrition·Sanda Nousia-ArvanitakisMichael Karamouzis
Jul 27, 2002·Journal of Pediatric Gastroenterology and Nutrition·Michael O Stormon, Peter R Durie
Nov 3, 2017·World Journal of Gastroenterology : WJG·Vikesh K SinghPedro M Quintana Diez
Oct 20, 2010·The Medical Journal of Australia·James ToouliUNKNOWN Australasian Pancreatic Club
Oct 18, 2003·Gastroenterology Clinics of North America·Raanan Shamir

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