Role of parametric resonance in virological failure during HIV treatment interruption therapy

Lancet
Romulus Breban, S M Blower

Abstract

We present a novel hypothesis that could explain virological failure to structured treatment interruptions (STI). We analysed a classic mathematical model of HIV within-host viral dynamics and found that non-linear parametric resonance occurs when STI are added to the model; resonance is observed as virological failure. We simulated clinical trial data and calculated patient-specific resonant spectra. We gained two important insights. First, within an STI trial, patients who begin with similar viral loads can be expected to show very different virological responses as a result of resonance. Second, and more importantly, virological failure is not simply due to STI or patients' characteristics; instead it is the result of complex interaction between STI and the patient's viral dynamics. Hence, our analyses show that no universal regimen with periodic interruptions will be effective for all patients.

References

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Citations

May 8, 2008·Journal of Mathematical Biology·Nicolas Bacaër, Xamxinur Abdurahman
Jan 21, 2010·Bulletin of Mathematical Biology·Michael Y Li, Hongying Shu
Jun 1, 2011·PloS One·Vincent C MarconiUNKNOWN Infectious Disease Clinical Research Program (IDCRP) HIV Working Group
Jul 13, 2013·Theoretical Biology & Medical Modelling·Leonardo OñaSebastian Bonhoeffer
Jan 15, 2008·Current Opinion in Infectious Diseases·Nicholas I Paton

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