Role of penA polymorphisms for penicillin susceptibility in Neisseria lactamica and Neisseria meningitidis

International Journal of Medical Microbiology : IJMM
André KarchHeike Claus

Abstract

In meningococci, reduced penicillin susceptibility is associated with five specific mutations in the transpeptidase region of penicillin binding protein 2 (PBP2). We showed that the same set of mutations was present in 64 of 123 Neisseria lactamica strains obtained from a carriage study (MIC range: 0.125-2.0mg/L). The PBP2 encoding penA alleles in these strains were genetically similar to those found in intermediate resistant meningococci suggesting frequent interspecies genetic exchange. Fifty-six N. lactamica isolates with mostly lower penicillin MICs (range: 0.064-0.38mg/L) exhibited only three of the five mutations. The corresponding penA alleles were unique to N. lactamica and formed a distinct genetic clade. PenA alleles with no mutations on the other hand were unique to meningococci. Under penicillin selective pressure, genetic transformation of N. lactamica penA alleles in meningococci was only possible for alleles encoding five mutations, but not for those encoding three mutations; the transfer resulted in MICs comparable to those of meningococci harboring penA alleles that encoded PBP2 with five mutations, but considerably lower than those of the corresponding N. lactamica donor strains. Due to a transformation barrie...Continue Reading

References

Feb 1, 1978·The Journal of Infectious Diseases·R GoldM Randolph
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B G SprattC G Dowson
Dec 1, 1987·Epidemiology and Infection·K A CartwrightN D Noah
Apr 1, 1998·Bioinformatics·D H Huson
Feb 27, 2001·The Journal of Antimicrobial Chemotherapy·A AntignacM K Taha
Apr 28, 2001·Journal of Clinical Microbiology·D AlberU Vogel
Sep 8, 2001·The New England Journal of Medicine·I LaurensonC Thompson
Feb 28, 2002·The Journal of Antimicrobial Chemotherapy·L ArreazaJ A Vázquez
Mar 19, 2005·The Journal of Infectious Diseases·Heike ClausUlrich Vogel
Mar 24, 2005·Infection and Immunity·Julia S BennettMartin C J Maiden
Dec 7, 2006·FEMS Microbiology Reviews·Julio A VázquezLuisa Arreaza
Jan 20, 2007·FEMS Microbiology Reviews·Simon Nadel, J Simon Kroll
May 23, 2007·Antimicrobial Agents and Chemotherapy·Muhamed-Kheir TahaMaria Leticia Zarantonelli
Feb 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Christoph SchoenMatthias Frosch
Dec 15, 2010·BMC Bioinformatics·Keith A Jolley, Martin C J Maiden
Oct 5, 2012·Journal of Clinical Microbiology·Paul A KristiansenDominique A Caugant

❮ Previous
Next ❯

Citations

Sep 14, 2015·International Journal of Medical Microbiology : IJMM·Ulrich VogelMary Slack
Jun 20, 2018·Antimicrobial Agents and Chemotherapy·Paola VaccaPaola Stefanelli
Nov 20, 2019·Antimicrobial Agents and Chemotherapy·Mingliang ChenMin Chen
Feb 1, 2020·International Journal of STD & AIDS·Antonella MarangoniMaria Carla Re

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.