PMID: 7739805Jan 16, 1995Paper

Role of peri-axonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain

Neuroscience Letters
A L ClatworthyE T Walters

Abstract

Loose ligation of a rat's sciatic nerve produces hyperalgesia to thermal stimuli and elicits guarding behavior directed at the afflicted paw. The present experiments test whether localized inflammation induced by the suture material used to ligate the nerve is critical to the development of hyperalgesia. Daily injections of dexamethasone reduced the inflammatory response induced by the sutures and blocked the development of guarding behavior and thermal hyperalgesia. In a second experiment inflammation associated with cotton sutures was enhanced by soaking the sutures in Freund's adjuvant prior to ligation. This caused an augmentation of thermal hyperalgesia and guarding behavior. These results suggest that inflammation around the nerve is critical for the development of guarding behavior and thermal hyperalgesia in this model of neuropathic pain.

References

Oct 12, 1992·Neuroscience Letters·K A Sluka, K N Westlund
Sep 30, 1991·Neuroscience Letters·S M CarltonR E Coggeshall
Nov 1, 1991·British Journal of Pharmacology·F Q CunhaS H Ferreira
Apr 15, 1994·Annals of the New York Academy of Sciences·A L ClatworthyE T Walters
Oct 1, 1993·Muscle & Nerve·G J Bennett
May 1, 1993·Journal of Neuropathology and Experimental Neurology·C SommerR R Myers

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Citations

Oct 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·D J Tracey, J S Walker
Jan 15, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Halina Machelska
Dec 27, 1995·European Journal of Pharmacology·M BianchiF Berti
Sep 1, 1996·Comparative Biochemistry and Physiology. Part A, Physiology·A L Clatworthy
Dec 4, 2003·Brain Research·T C B SchützS Tufik
Nov 8, 2001·European Journal of Pharmacology·E W Boddeke
Mar 29, 2001·Pharmacology, Biochemistry, and Behavior·J M TallT Crisp
Feb 13, 1999·Progress in Neurobiology·M J Millan
Dec 13, 2000·Neuroscience·N M Perkins, D J Tracey
Dec 1, 1999·Neuroscience·J P SyriatowiczD J Tracey
Apr 20, 2000·Neuroscience·T LiuD J Tracey
Oct 6, 2000·Journal of Pain and Symptom Management·R J Dunlop, C W Campbell
Aug 1, 1997·Journal of Pain and Symptom Management·L A Martin, N A Hagen
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Tanya R WallasGeoffrey M Bove
Sep 29, 1998·The European Journal of Neuroscience·D Levy, D W Zochodne
Jan 20, 2009·Human Reproduction·Guoyun WangIan S Fraser
Jul 20, 2002·Regional Anesthesia and Pain Medicine·Quinn Hogan
May 5, 1999·Fundamental & Clinical Pharmacology·M BianchiA E Panerai
Feb 7, 2001·Annual Review of Psychology·L R Watkins, S F Maier
Oct 19, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Guohua ZhangKaren J Berkley
Jul 31, 2007·BMC Neuroscience·Michael A HenryS Rock Levinson
Apr 20, 2010·Journal of Neuroinflammation·Lawrence Leung, Catherine M Cahill
Oct 3, 2013·Journal of Molecular Neuroscience : MN·Federica GinanneschiAlessandro Rossi
Aug 21, 2013·Progress in Neurobiology·C Patte-MensahA G Mensah-Nyagan
Feb 9, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·H Evren EkerGulnaz Arslan
May 12, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Donna J MillingtonJason Obirek
Jul 7, 2009·Psychoneuroendocrinology·Ayikoe G Mensah-NyaganChristine Patte-Mensah
May 1, 2009·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Ilona Klusáková, Petr Dubový

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