PMID: 2098713Dec 1, 1990Paper

Role of pH in salivary histidine-rich polypeptide antifungal germ tube inhibitory activity

Oral Microbiology and Immunology
E C BrantJ J Pollock

Abstract

Purified synthetic salivary histidine-rich polypeptides (HRPs) 2, 3, 4, 5 and 6 were found to inhibit Candida albicans conversion of blastospores to germ tubes. HRP-4 was the best inhibitor within the pH 5 to 7 range tested and all of the HRPs were observed to lose potency as the pH was raised from 5 to 7. The pH pattern obtained with a synthetic homologous histidine peptide suggested that the protonated form of the histidine imidazole residues of the HRPs was important to the germ tube antifungal activity. Similar pH inhibition profiles of germ tube formation by parotid saliva and the HRPs were also observed.

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Citations

Nov 4, 2000·Expert Opinion on Investigational Drugs·A J De Lucca
Nov 24, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H Tsai, L A Bobek
May 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·I D MandelL Turgeon
Oct 1, 1992·Oral Microbiology and Immunology·M Lenander-Lumikari
Aug 1, 1995·Oral Microbiology and Immunology·M Lenander-Lumikari, I Johansson
Feb 1, 1992·Oral Microbiology and Immunology·R P SantarpiaJ J Pollock
Jan 16, 1999·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·J G BercierF G Oppenheim

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