Role of phagocytosis in activation of the coagulation system in Streptococcus sanguis endocarditis.

Infection and Immunity
M J BancsiJ Thompson

Abstract

The formation of vegetations consisting of fibrin, cellular elements, humoral factors, and bacteria is the central event in the pathogenesis of bacterial endocarditis. Fibrin formation occurs on the vegetation, the coagulation system being activated locally via the expression of tissue factor (TF) on fibrin-adherent monocytes. This study was performed to assess the importance of phagocytosis of fibrin-adherent Streptococcus sanguis in the stimulation of TF expression on fibrin-adherent monocytes, as well as a role for "frustrated" phagocytosis. With the latter process, these cells are unable to remove bacteria from the fibrin surface but nonetheless might be activated to generate TF. We found that serum was not required for the stimulation of TF expression by fibrin-adherent monocytes in the presence of S. sanguis in an in vitro model for bacterial endocarditis. The bacterial adhesin dextran did not influence the TF activity (TFA) of fibrin-adherent monocytes: TFA was the same after stimulation with a dextran-positive streptococcus as with its dextran-negative mutant. Furthermore, dextran did not influence the TFA of endocardial vegetations, which was the same for vegetations isolated from rabbits infected either with dextran-p...Continue Reading

References

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Citations

Sep 2, 2016·Nature Reviews. Disease Primers·Thomas L HollandVance G Fowler
Nov 20, 2013·Nature Reviews. Cardiology·Karl WerdanUrsula Müller-Werdan
Feb 23, 2007·Journal of Dental Research·C-L HahnJ G Tew
Jul 3, 2002·Infectious Disease Clinics of North America·Philippe MoreillonArnold S Bayer

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