Role of pharmacogenetics of drug-metabolizing enzymes in treating osteosarcoma

Expert Opinion on Drug Metabolism & Toxicology
Claudia Maria Hattinger, Massimo Serra

Abstract

Drug-metabolizing enzymes (DMEs) biotransform several toxins and xenobiotics in both tumor and normal cells, resulting in either their detoxification or their activation. Since DMEs also metabolize several chemotherapeutic drugs, they can significantly influence tumor response to chemotherapy and susceptibility of normal tissues to collateral toxicity of anticancer treatments. This review discusses the pharmacogenetics of DMEs involved in the metabolism of drugs which constitute the backbone of osteosarcoma (OS) chemotherapy, highlighting what is presently known for this tumor and their possible impact on the modulation of future treatment approaches. Achieving further insight into pharmacogenetic markers and biological determinants related to treatment response in OS may ultimately lead to individualized treatment regimens, based on a combination of genotype and tumor characteristics of each patient.

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Citations

Jun 1, 2016·The Pharmacogenomics Journal·M Serra, C M Hattinger
Jun 30, 2016·Drug Discovery Today·Hanneke I VosDunja Maroeska W M Te Loo
Oct 21, 2016·Rheumatology and Therapy·Ryan A DurfeeHue H Luu
Dec 7, 2017·International Journal of Cancer. Journal International Du Cancer·Roelof KosterLisa Mirabello
Mar 2, 2019·Expert Opinion on Drug Metabolism & Toxicology·Claudia Maria HattingerMassimo Serra
Apr 17, 2020·Journal of Adolescent and Young Adult Oncology·Alini Trujillo-PaolilloSílvia R C Toledo
Apr 17, 2020·Cells·Katia ScotlandiMassimo Serra
Apr 14, 2017·Oncotarget·Alini Trujillo-PaolilloSilvia Regina Caminada de Toledo
Mar 25, 2017·Nature Reviews. Endocrinology·D Matthew GianferanteSharon A Savage
Oct 17, 2018·Expert Review of Molecular Diagnostics·Claudia Maria HattingerMassimo Serra

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