PMID: 6125456Jan 1, 1982

Role of phosphatases in the biosynthesis of chlortetracycline in Streptomyces aureofaciens

Folia Microbiologica
V JechováZ Hostálek


ATP diphosphohydrolase activity and inorganic pyrophosphatase reached two maxima during cultivation of the low- and high-producing variant of Streptomyces aureofaciens under conditions of phosphate limitation, i.e. after 30 and 70 h of cultivation. Increased levels of inorganic phosphate in a medium inhibitory to biosynthesis of chlortetracycline markedly decreased the levels of both enzymes. The ATP diphosphohydrolase activity was detected both in the supernatant and membrane fractions of the cell-free preparation of the mycelium.


Jan 1, 1976·Folia Microbiologica·Z HostálekI S Kulayev
Jan 1, 1982·Folia Microbiologica·E CurdováZ Hostálek
Jan 1, 1980·Folia Microbiologica·Z Hostálek
Aug 1, 1949·Journal of the American Pharmaceutical Association·J LEVINEH FISCHBACH


Jan 1, 1983·Zeitschrift für allgemeine Mikrobiologie·B BrücknerR Tröger
Jan 1, 1984·Zeitschrift für allgemeine Mikrobiologie·P J MüllerH Bocker
Jan 1, 1976·Folia Microbiologica·Z HostálekI S Kulayev
Jan 1, 1982·Folia Microbiologica·E CurdováZ Hostálek
May 1, 1997·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·L GarcíaM A Valenzuela
Jan 1, 1983·Biotechnology Advances·R Hütter, P Niederberger
Jan 1, 1986·Journal of Basic Microbiology·S Kretschmer

Related Concepts

Chlortetracycline Sulfate (2: 1)
Tissue Membrane
Phosphoric Monoester Hydrolases

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