PMID: 6979351Apr 29, 1982Paper

Role of phospholipase A2 and prostaglandin E in growth and differentiation of myeloid leukemic cells

Biochimica Et Biophysica Acta
R Simantov, L Sachs

Abstract

Phospholipase A2 activity and prostaglandin E synthesis have been studied in different clones of myeloid leukemic cells, which differ in their competence to be induced to differentiate by the macrophage and granulocyte differentiation-inducing protein or the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA). Clones that could be induced to differentiate by this protein showed a higher basal phospholipase A2 activity than clones that could not be induced to differentiate by this protein inducer. Cell competence to be induced to differentiate by TPA did not show this correlation, and the clone with the least ability to respond to TPA showed the lowest number of binding sites for [20-3H]phorbol 12,13-dibutyrate. Differentiation induced by the protein was accompanied by a 7-14-fold increase in prostaglandin E synthesis, whereas differentiation induced by TPA did not show this increase. Externally added prostaglandin E1 did not induce differentiation but inhibited cell proliferation and the degree of inhibition in the different clones was related to the basal phospholipase A2 activity. The results indicate that increase of prostaglandin E synthesis was not an essential pre-requisite for differentiation, that prostaglandin E...Continue Reading

References

Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R Simantov, L Sachs
Jan 1, 1978·Annual Review of Biochemistry·B SamuelssonC Malmsten
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·B Weiss, L Sachs
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J Lotem, L Sachs
Feb 1, 1976·Biochemical Pharmacology·R J Flower, G J Blackwell
Jan 1, 1976·Journal of Immunological Methods·S Bauminger
May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S L Hong, L Levine
Jul 13, 1972·European Journal of Biochemistry·E T RietschelO Westphal
Apr 30, 1971·Annals of the New York Academy of Sciences·H Kunze, W Vogt
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P MallorgaJ Axelrod
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R SimantovL Sachs
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R DulbeccoM Unger
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P E Driedger, P M Blumberg

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Citations

Aug 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M JuzanN Gualde
Oct 1, 1988·Current Problems in Surgery·B M JaffeK Kimura
Apr 15, 1983·International Journal of Cancer. Journal International Du Cancer·R SimantovL Sachs

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