Role of phospholipases in adrenal steroidogenesis

The Journal of Endocrinology
Wendy B Bollag

Abstract

Phospholipases are lipid-metabolizing enzymes that hydrolyze phospholipids. In some cases, their activity results in remodeling of lipids and/or allows the synthesis of other lipids. In other cases, however, and of interest to the topic of adrenal steroidogenesis, phospholipases produce second messengers that modify the function of a cell. In this review, the enzymatic reactions, products, and effectors of three phospholipases, phospholipase C, phospholipase D, and phospholipase A2, are discussed. Although much data have been obtained concerning the role of phospholipases C and D in regulating adrenal steroid hormone production, there are still many gaps in our knowledge. Furthermore, little is known about the involvement of phospholipase A2, perhaps, in part, because this enzyme comprises a large family of related enzymes that are differentially regulated and with different functions. This review presents the evidence supporting the role of each of these phospholipases in steroidogenesis in the adrenal cortex.

References

Jan 1, 1992·Methods in Enzymology·R N Lemaitre, J A Glomset
May 1, 1991·Molecular and Cellular Biology·M H TsaiD W Stacey
Nov 1, 1989·Endocrine Reviews·P Q BarrettH Rasmussen
Sep 1, 1988·The Journal of Clinical Endocrinology and Metabolism·R NatarajanJ Nadler
Oct 31, 1988·Biochemical and Biophysical Research Communications·R NatarajanJ Nadler
Jun 1, 1985·Molecular and Cellular Endocrinology·P EnyediA Spät
Jun 1, 1994·Journal of Biochemistry·S Nakamura, Y Nishizuka
Aug 1, 1996·Current Biology : CB·M A Frohman, A J Morris
May 18, 2001·Journal of Molecular Endocrinology·R SirianniW E Rainey
May 30, 2001·Molecular and Cellular Endocrinology·S Betancourt-CalleW Bollinger Bollag
Jul 10, 2001·American Journal of Physiology. Cell Physiology·G CzirjákP Enyedi
Mar 2, 2002·Journal of Biochemistry·Makoto Murakami, Ichiro Kudo
Jun 29, 2002·Molecular and Cellular Endocrinology·Wendy B BollagRoberto A Calle
Feb 1, 2003·FEBS Letters·Miriam RábanoAntonio Gómez-Muñoz
Aug 29, 2003·Molecular and Cellular Endocrinology·Xiangjian Zheng, Wendy B Bollag

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Citations

Dec 4, 2016·The Journal of Endocrinology·Ying-Ying TsaiWendy B Bollag
Jan 5, 2021·Applied Microbiology and Biotechnology·Shi-Huan LiJia-Xun Feng

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