Role of phytoestrogens in prevention and management of type 2 diabetes

World Journal of Diabetes
Mohammad Talaei, An Pan

Abstract

Type 2 diabetes (T2D) has become a major public health threat across the globe. It has been widely acknowledged that diet plays an important role in the development and management of T2D. Phytoestrogens are polyphenols that are structurally similar to endogenous estrogen and have weak estrogenic properties. Emerging evidence from pre-clinical models has suggested that phytoestrogens may have anti-diabetic function via both estrogen-dependent and estrogen-independent pathways. In the current review, we have summarized the evidence linking two major types of phytoestrogens, isoflavones and lignans, and T2D from epidemiological studies and clinical trials. The cross-sectional and prospective cohort studies have reported inconsistent results, which may due to the large variations in different populations and measurement errors in dietary intakes. Long-term intervention studies using isoflavone supplements have reported potential beneficial effects on glycemic parameters in postmenopausal women, while results from short-term small-size clinical trials are conflicting. Taken together, the current evidence from different study designs is complex and inconsistent. Although the widespread use of phytoestrogens could not be recommended y...Continue Reading

Citations

May 11, 2017·European Journal of Clinical Nutrition·C T NguyenA H Lee
Jul 12, 2018·Critical Reviews in Food Science and Nutrition·Hui CaoJianbo Xiao
Dec 6, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Samantha N FreedmanAshutosh K Mangalam
Dec 5, 2018·Expert Review of Neurotherapeutics·Ashutosh K Mangalam, Joseph Murray
Mar 1, 2019·Molecular Nutrition & Food Research·Clare WhittonRob M van Dam
Oct 11, 2017·Current Medicinal Chemistry·Antonella SmeriglioErsilia Bellocco
Jun 12, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Zohreh EsfandiarFereidoun Azizi
Feb 28, 2020·Nutrients·Alina KuryłowiczMonika Puzianowska-Kuźnicka
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomislav PejčićŽivoslav Tešić
Oct 1, 2016·Journal of Medicinal Food·María G Soto-ZarazúaMaria Beatriz P P Oliveira
Jan 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Patrik A RunebergPatrik C Eklund
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yimin YinZhuoqin Jiang
Jun 19, 2021·Frontiers in Endocrinology·Karina Ramírez-AlarcónMiquel Martorell

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