Role of plasminogen activator inhibitor-1 in the diagnosis and prognosis of patients with Parkinson's disease

Experimental and Therapeutic Medicine
Hong PanLiandong Zhao

Abstract

Parkinson's disease is a neurodegenerative disease that frequently results in memory disorders, cognitive decline and dementia. Previous studies have reported that plasminogen activator inhibitor-1 (PAI-1) serves an important role in cardiovascular disease risk, adiposity, insulin resistance and inflammation. However, the role of PAI-1 in diagnosis and prognosis of patients with Parkinson's disease following deep brain stimulation (DBS) has not reported, to the best of our knowledge. Therefore, the purpose of the present study was to investigate the clinical significance of PAI-1 in patients with Parkinson's disease. Plasma PAI-1 levels were measured in 102 patients with Parkinson's disease who underwent DBS. It was demonstrated that plasma PAI-1 levels were significantly increased in patients with Parkinson's disease compared with healthy individuals (P<0.01). Patients with Parkinson's disease received DBS presented significantly improved cognitive competence compared with controls (P<0.01). DBS significantly decreased plasma PAI-1 levels in patients with Parkinson's disease compared with controls (P<0.05). It was also observed that plasma PAI-1 levels were significantly negatively associated with cognitive function for patien...Continue Reading

References

Jul 19, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Matthias J WieserAndreas Mühlberger
Aug 2, 2011·The Journal of Toxicological Sciences·Ioannis A ZervosIoannis A Taitzoglou
Nov 8, 2011·European Neurology·Hiroshi KataokaSatoshi Ueno
Mar 12, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Philippe Leroux, Stéphane Marret
Feb 7, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Patricia M NunesArend Heerschap
Nov 12, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Barbara NowackaKrzysztof Safranow
Nov 15, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Shang-Ming ChiouChon-Haw Tsai
May 20, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Deborah ElsteinAri Zimran
Nov 29, 2015·Aging Clinical and Experimental Research·Malgorzata Gorska-CiebiadaJerzy Loba
Nov 20, 2016·Neurology·Tadaaki ManoThomas Britton
Nov 24, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sanne K MelesKlaus L Leenders
Dec 3, 2016·Journal of the International Neuropsychological Society : JINS·Christine A Cooper, Lama M Chahine
Dec 17, 2016·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Kathryn A Wyman-ChickRyan W Schroeder
Dec 18, 2016·Neurology·Lena K TholfsenMichaela D Gjerstad
Oct 31, 2017·Behavioural Neurology·Márton KovácsNorbert Kovács

❮ Previous
Next ❯

Citations

Sep 29, 2020·Frontiers in Neuroscience·María Teresa Flores-DorantesRuth Gutiérrez-Aguilar
Apr 4, 2021·International Journal of Molecular Sciences·Machteld Sillen, Paul J Declerck
May 1, 2021·International Journal of Molecular Sciences·Manuel YepesCynthia Martin-Jimenez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Related Papers

Journal of Pediatric Endocrinology & Metabolism : JPEM
Rafael M MantovaniAna Cristina Simões e Silva
Nihon rinsho. Japanese journal of clinical medicine
S IwabuchiT Hayashi
Nihon rinsho. Japanese journal of clinical medicine
Jun Mimuro
© 2022 Meta ULC. All rights reserved