Role of platelet-activating factor (PAF) in the bronchopulmonary alterations and beta-adrenoceptor function induced by endotoxin

Biochemical and Biophysical Research Communications
C TouvayP Braquet

Abstract

The possibility that PAF is implicated in the alterations of the beta-adrenoceptor function observed during endotoxemia was investigated. Lung parenchymal strips (LPS) from endotoxin-treated guinea-pig demonstrated specific desensitization to low doses of PAF whereas the contractions induced by histamine and leukotriene D4 were slightly affected. In addition, histamine-contracted LPS from endotoxin-injected animals exhibited decreased responsiveness to isoproterenol, a phenomenon not observed with guinea-pigs also treated with the specific PAF antagonist, BN 52021. No alteration of the sensitivity to isoproterenol of LPS preincubated with PAF was noted, suggesting an indirect effect of the autacoid on beta-adrenoceptor function.

References

Apr 1, 1987·British Journal of Pharmacology·P J BarnesD N Robertson
Feb 1, 1985·Immunopharmacology·P IñarreaM Sánchez-Crespo
Feb 26, 1985·European Journal of Pharmacology·Z TerashitaS Sumida

Citations

Jan 1, 1990·Pharmacology & Therapeutics·R G GoldieK M Lulich
Jul 1, 1997·The British Journal of Surgery·M G Davies, P O Hagen

Related Concepts

Metazoa
Endotoxins
Cavia porcellus
Ceplene
Novodrin
Lung
Inotropism
Muscle Relaxation Phase
Platelet Activating Factor
Beta-adrenergic receptor

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.