Role of platelet-derived chemokines (RANTES and ENA-78) after stem cell transplantation

Transplant Immunology
Shosaku NomuraKunio Hayashi

Abstract

Stem cell transplantation (SCT) is being used for hematopoietic reconstitution following high-dose chemotherapy for malignancy. Some patients seem to have an imbalance of the immune response after SCT and cytokines are known to regulate this response. Recently, platelets have been shown to contain members of the chemokine family, suggesting a role of platelets as inflammatory cells. We measured and compared levels of platelet activation markers, chemokines, and soluble factors in patients undergoing SCT. IL-8 and GROalpha exhibited a significant elevation in the early phase (1 or 2 weeks) after SCT; this trend was marked after autologous SCT. Furthermore, these levels significantly and positively correlated with the change in G-CSF. In contrast, ENA-78 exhibited a significant elevation in the later phase (3 or 4 weeks) after SCT. In addition, its level negatively correlated with the change in G-CSF. Soluble CD40 ligand and platelet-derived microparticles significantly increased after both auto- and allo-SCT. In addition, ENA-78 positively correlated with the level of platelet-derived microparticles. The increase of RANTES seems to be related to platelet activation, since RANTES was in the dynamic phase similar to soluble CD40 l...Continue Reading

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Citations

Aug 1, 2008·Thrombosis Research·Shosaku NomuraYasuo Ikeda
Sep 10, 2011·Equine Veterinary Journal·B DunkelF M Cunningham
Feb 24, 2015·Journal of Intensive Care·Shosaku Nomura, Michiomi Shimizu
Jun 11, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Shosaku NomuraKunio Hayashi
Nov 25, 2006·Virchows Archiv : an International Journal of Pathology·Shigeki ShimizuRyuzo Ueda
Jan 29, 2017·International Journal of Hematology·Shosaku Nomura
Aug 28, 2021·World Journal of Transplantation·Masayuki Nagasawa

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