Role of platelet gel and calcium-coated Lactosorb membranes in healing critical calvarial defects

The Journal of Craniofacial Surgery
Daniel A Peters, Douglas J Courtemanche

Abstract

We evaluated the efficacy of coating Lactosorb (Biomet Inc, Warsaw, IN) membranes with calcium hydroxyapatite in critical-size defects in rabbits. We also evaluated whether platelet gel affects calvarial bone healing.Fifteen adult New Zealand white rabbits were divided into 5 groups. Each animal underwent a surgical procedure in which 2 critical-size (15 mm) calvarial defects were created in the parietal bones. Group A was control. Group B was a control in 1 defect and Lactosorb in the other defect. Group C was treated with Lactosorb in 1 defect and Lactosorb coated with calcium hydroxyapatite in the other defect. Group D was treated with Lactosorb in 1 defect and coated Lactosorb without calcium hydroxyapatite in the other defect. Group E was treated with platelet gel in 1 defect and control in the other. The animals were killed at 1, 3, and 6 months. The bones were excised and evaluated by clinical observation, radiography, and histology.None of the defects were closed at 6 months. Defects treated with platelet gel healed in a similar fashion as control. All defects treated with a barrier (Lactosorb, Lactosorb coated, Lactosorb coated with hydroxyapatite) showed clinical, radiographic, and histologic evidence of increased hea...Continue Reading

References

Aug 1, 1992·Plastic and Reconstructive Surgery·P D CostantinoG A Sisson
Aug 1, 1992·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·D LundgrenB Klinge
Aug 2, 2000·The British Journal of Oral & Maxillofacial Surgery·F WatzingerR Ewers
Apr 17, 2001·Plastic and Reconstructive Surgery·J AschermanD T Chiu
Apr 21, 2001·The Journal of Craniofacial Surgery·S StalL Hollier
Apr 21, 2001·The Journal of Craniofacial Surgery·B L Eppley
Jul 17, 2001·Journal of Periodontology·L MarinucciP Locci
Mar 12, 2002·The Journal of Craniofacial Surgery·Cameron M L ClokieGeorge K B Sandor
May 22, 2002·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M RobionyM Politi
Feb 6, 2004·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Hassan G MoghadamCameron M L Clokie
Apr 6, 2004·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Gabriella GianniniBindi Gianfranco

❮ Previous
Next ❯

Citations

Feb 18, 2012·The Journal of Craniofacial Surgery·Adam J OppenheimerSteven R Buchman
Apr 5, 2013·Journal of Biomedical Materials Research. Part a·Ashley MitchellJ Patrick O'Connor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.