Role of platelet-rich plasma in acceleration of bone fracture healing

Annals of Plastic Surgery
Richard SimmanAndrew J Russ

Abstract

Platelet-rich plasma (PRP) is a common therapy for acceleration of maxillofacial and spinal fusion bone-graft healing. This study analyzes the therapeutic role of PRP during long-bone fracture healing evaluated Lewis rats. Following creation of unilateral open femur fractures, either 500 microL thrombin-activated PRP (PRP treated group) or 500 microL saline (control group) were applied once to the fracture site. Fracture healing was analyzed after 1 and 4 weeks. Following 4 weeks of fracture healing, radiographic analysis demonstrated higher callus to cortex width ratio (P < 0.05) in the PRP group (PRP: 1.65 +/- 0.06; control: 1.48 +/- 0.05). Three-point load bearing showed increased bone strength following PRP treatment (PRP: 60.85 +/- 6.06 Newton, control: 47.66 +/- 5.49 Newton). Fracture histology showed enhanced bone formation in the PRP group. Immunohistochemistry and Western-blotting demonstrated healing-associated changes in transforming growth factor (TGF)-beta1 and bone morphogenetic protein (BMP)-2. Our results suggest that PRP accelerates bone fracture healing of rat femurs via modulation of TGF-beta1 and BMP-2 growth factor expression.

References

Jan 1, 1992·Bone·B Bak, K S Jensen
Nov 1, 1981·Acta Endocrinologica·T T AndreassenH Oxlund
Jul 1, 1993·Bone·C H Turner, D B Burr
Jun 4, 1998·Biochemical and Biophysical Research Communications·E MisugiS Morooka
Jun 25, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·R E MarxK R Georgeff
Aug 24, 1999·Bone·G L LoweryA E Pennisi
Apr 25, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·H M AminJ Fareed
Feb 5, 2002·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Dennis A ChakkalakalTerrence M Donohue
Oct 29, 2004·Plastic and Reconstructive Surgery·Barry L EppleyJoel Higgins

❮ Previous
Next ❯

Citations

Nov 3, 2010·Tissue Engineering. Part B, Reviews·Diederik H R KempenWouter J A Dhert
Mar 3, 2011·Plastic and Reconstructive Surgery·Benjamin LeviMichael T Longaker
Aug 26, 2010·The Journal of Oral Implantology·Ricardo V GarciaJamil A Shibli
Jun 12, 2013·Orthopedics·Linwei ChenWanli Li
Jan 25, 2014·Current Osteoporosis Reports·Julie A Sterling, Scott A Guelcher
Feb 19, 2011·Journal of Biomedicine & Biotechnology·Michael FrinkFrank Hildebrand
Oct 3, 2009·Journal of Cell Communication and Signaling·Kumi SumiyoshiMasaharu Takigawa
Dec 15, 2012·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·C E SommelingS Monstrey
Nov 19, 2010·Ultrasound in Medicine & Biology·Angela NotarnicolaBiagio Moretti
Jun 23, 2009·Burns : Journal of the International Society for Burn Injuries·Norbert PalluaMarta Markowicz
Apr 3, 2012·Journal of Pineal Research·William P ClafshenkelPaula A Witt-Enderby
Jul 13, 2011·Clinical Implant Dentistry and Related Research·Jaan HongAndreas Thor
Dec 2, 2009·Journal of Cellular Biochemistry·David E Komatsu, Stuart J Warden
Sep 18, 2013·Journal of Oral Science·Luiz A M PenteadoBruno C V Gurgel
Oct 31, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Yunus GuzelMahmut Nedim Doral
Feb 14, 2017·The Journal of Veterinary Medical Science·Vanessa FaillaceFulvio Laus
Jun 24, 2017·Platelets·Sabrina MarcazzanMassimo Del Fabbro
Nov 24, 2017·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Gipson SamuelGayadhar Behera
Mar 22, 2015·Annals of Biomedical Engineering·Benjamin D ElderTimothy F Witham
May 4, 2012·The Journal of Bone and Joint Surgery. American Volume·N Lindsay HarrisMark L Purnell
Jul 25, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Timothy L MillerScott A Rodeo
May 2, 2018·BioImpacts : BI·Navid Hosseini MansoubGulinnaz Ercan
Mar 8, 2020·International Journal of Molecular Sciences·Francesca SalamannaMilena Fini
Nov 20, 2013·Experimental and Therapeutic Medicine·César RiveraIván Suazo
Apr 26, 2016·Tissue Engineering. Part B, Reviews·Ryosuke Sakata, A Hari Reddi
Jul 4, 2020·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Koray BaşdelioğluDevrim Akseki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Bone and Joint Surgery. American Volume
Don M RanlyZvi Schwartz
The American Journal of Sports Medicine
Timothy E FosterScott A Rodeo
Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Yawei LiuOla Wahlström
Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Earl G Freymiller
© 2022 Meta ULC. All rights reserved