Role of platelet surface glycoprotein Ibalpha and P-selectin in the clearance of transfused platelet concentrates

Transfusion
Valery LeytinJohn Freedman

Abstract

Role of P-selectin (CD62) and glycoprotein (GP) Ibalpha in posttransfusion clearance of platelet concentrates (PCs) is unclear. Platelet (PLT) activation in vitro was determined by flow cytometry using anti-CD62 and anti-GPIbalpha. PC clearance in vivo was evaluated in an animal model using rabbits with an inhibited reticuloendothelial system, as measured by 0.5-hour (R(0.5)), 24-hour (R(24)), and total (R( summation operator )) PLT recoveries, and survival time (ST). Correlations were analyzed between in vitro assays of PLT activation and in vivo clearance of conventional (Days 2-5), outdated (Days 7-8), and refrigerated PCs. Binding of anti-CD62 to the PLT surface was significantly increased and of anti-GPIbalpha decreased in outdated and refrigerated PCs compared to conventional PCs. Negative correlation was observed between in vitro anti-CD62 binding and the fast (R(0.5)) PLT clearance, but not with delayed (R(24) and ST) clearance. In contrast, anti-GPIbalpha binding showed positive correlations with delayed but not with fast PLT clearance. Overall (R( summation operator )) clearance correlated better with anti-GPIbalpha than with anti-CD62 binding. CD62 density on the PLT surface was decreased after PC transfusion, wherea...Continue Reading

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Citations

Feb 6, 2016·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Mallikarjun HandigundYong Gon Cho
May 24, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Susanne M Picker
Nov 26, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Viktoria Rumjantseva, Karin M Hoffmeister
Aug 25, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Nahreen Tynngård
Aug 25, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Tomas L Lindahl, Sofia Ramström
Sep 2, 2008·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·T ChakrounS Yacoub
May 31, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Shinji OikawaHiroshi Shimizu
Sep 29, 2007·Transfusion Medicine Reviews·Sandra CauwenberghsJohan W M Heemskerk
May 15, 2007·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·F CognasseO Garraud
Mar 25, 2005·Vox Sanguinis·Rebecca CardiganPaul Harrison
Jan 30, 2009·Transfusion·Gabriele StieglerChristine Mannhalter
Sep 27, 2007·Transfusion·Petra Jilma-StohlawetzSimon Panzer
Dec 11, 2007·Transfusion·Friedgard JulmyKurt Leibundgut
Aug 29, 2006·Transfusion·Bahram A BadlouJan-Willem N Akkerman
Sep 21, 2007·Transfusion·David W C DekkersDirk de Korte
Mar 5, 2013·Artificial Organs·Kang ZhouZhongjun J Wu
Nov 3, 2011·Transfusion·Nahreen TynngårdGösta Berlin
Jun 15, 2011·Vox Sanguinis·S Panzer, P Jilma
Aug 4, 2011·Journal of Thrombosis and Haemostasis : JTH·K M Hoffmeister
Jan 21, 2010·Journal of Clinical Laboratory Analysis·Il Joong ParkSung Ran Cho
Jul 29, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·C Robert Valeri, Gina Ragno
May 28, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Yousheng LiJieshou Li

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