PMID: 7038856Jan 1, 1981

Role of platelets in the development of atherosclerotic disease and possible interference with platelet inhibitor drugs

Scandinavian Journal of Haematology. Supplementum
V Fuster

Abstract

During the last two decades, significant advances have been made in the understanding of atherosclerotic disease. The pathogenesis of atherosclerosis appears to depend on a precise sequence of critical events based on the interaction of blood elements and lipids with the arterial wall. The major critical events and their sequence appears to be as follows: hemodynamic stress and endothelial injury; arterial wall-platelet interaction; smooth muscle cell proliferation; lipid entry and accumulation; significant arterial narrowing with fibrosis and development of thrombi; and complications in the form of calcification, ulceration, aneurysm, acute thrombotic occlusion and embolization. This sequence of critical events starts at a young age and in all geographic racial groups. Their evolution into advanced symptomatic lesions takes many years and varies in incidence and extent among different geographic and ethnic groups. It appears that in promoting and accelerating this process into the advanced stage of the disease, the presence at a young age of the so-called risk factors of atherosclerotic disease is most important. The recent advances in the understanding of the atherosclerotic process will be highlighted in this chapter with pa...Continue Reading

References

Dec 1, 1976·Prostaglandins·N WhittakerF F Sun
Oct 6, 1977·The New England Journal of Medicine·W RubermanS Shapiro
Sep 1, 1979·Lancet·H SinzingerK Silberbauer
Dec 22, 1979·Lancet·P C Elwood, P M Sweetnam
Jun 17, 1976·The New England Journal of Medicine·M S Brown, J L Goldstein
May 17, 1979·The New England Journal of Medicine·S Moncada, J R Vane
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H N AntoniadesC D Stiles
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F M BooyseE J Bowie
Jun 1, 1979·The American Journal of Cardiology·M P MetkeM P Kaye
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·B B WekslerE A Jaffe
Feb 9, 1978·The New England Journal of Medicine·Anturane Reinfarction Trial Research Group
Jun 1, 1978·Cell·R Ross, A Vogel
Nov 1, 1978·Atherosclerosis·C J MorrisK W Walton
Aug 1, 1979·Circulation·R E VlietstraL R Elveback
Aug 16, 1979·The New England Journal of Medicine·P ThérouxH F Mizgala
Jun 1, 1979·Atherosclerosis·C Velican, D Velican
Jun 1, 1979·Atherosclerosis·D Velican, C Velican
Aug 1, 1979·Atherosclerosis·J L Kadish
Nov 1, 1978·Thrombosis Research·Y J LegrandJ P Caen
Nov 1, 1977·Acta Physiologica Scandinavica·J Svensson, B B Fredholm
Oct 5, 1978·The New England Journal of Medicine·H L GreeneA H Schaeffer
Aug 12, 1976·The New England Journal of Medicine·R Ross, J Glomset
Sep 17, 1976·Science·R Ross, L Harker
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
May 22, 1975·Biochimica Et Biophysica Acta·E L Bierman, J J Albers
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R RossL Harker
Jan 27, 1972·The New England Journal of Medicine·M E Grant, D J Prockop
Apr 1, 1973·The Journal of Clinical Investigation·M B Bernik
Jul 1, 1971·The Journal of Cell Biology·R Ross, S J Klebanoff
Jan 1, 1974·Advances in Lipid Research·E B Smith
Jan 1, 1974·Perspectives in Biology and Medicine·D W Urry
Dec 8, 1972·Annals of the New York Academy of Sciences·K LakiJ Farrell
May 1, 1974·Thrombosis Research·M A HowardR M Hardisty
Jan 1, 1973·The Medical Clinics of North America·S Glagov
Jan 1, 1974·Seminars in Arthritis and Rheumatism·M E Nimni
Oct 1, 1972·The Journal of Experimental Medicine·M B Stemerman, R Ross
Feb 14, 1973·Biochimica Et Biophysica Acta·H V KothariD Kritchevsky
Jan 1, 1974·Advances in Experimental Medicine and Biology·S Y Yu
Jan 1, 1967·Advances in Lipid Research·A J Day
Jan 1, 1968·Journal of Atherosclerosis Research·H J KnieriemR W Wissler
Apr 1, 1969·The Journal of Pathology·N Woolf, K C Carstairs
Jan 1, 1968·Advances in Lipid Research·R W Wissler, D Vesselinovitch
Jan 1, 1972·Circulation·W C Roberts
Jan 1, 1972·Atherosclerosis·H P Wright
May 1, 1971·Atherosclerosis·J B Somer, C J Schwartz
Oct 1, 1965·Physiological Reviews·D S Goodman
Jun 1, 1968·Experimental and Molecular Pathology·R FLORENTINK D Miller
Oct 1, 1967·Experimental and Molecular Pathology·M A PackhamJ F Mustard
Dec 1, 1967·Circulation Research·H C Kwaan, T Astrup
Jan 1, 1980·Atherosclerosis·J F CornhillA B Chandler
May 1, 1980·Atherosclerosis·M L ArmstrongW R Clarke
Jan 31, 1980·The New England Journal of Medicine·Anturane Reinfarction Trial Research Group
Aug 1, 1980·Science·I D GoldbergR I Handin
Jun 1, 1980·Atherosclerosis·R M Nerem, J F Cornhill
Oct 16, 1980·The New England Journal of Medicine·M A DeWoodH T Lang
Dec 1, 1960·Proceedings of the Society for Experimental Biology and Medicine·L SWELLC R TREADWELL
Apr 1, 1963·British Journal of Haematology·P CORNUJ BERNARD
Oct 1, 1964·Experimental and Molecular Pathology·A DAOUDR FLORENTIN
Jul 16, 1955·Journal of the American Medical Association·W F ENOSR H HOLMES
Jun 1, 1947·Proceedings of the Society for Experimental Biology and Medicine·K R PORTER, C V Z HAWN
Jul 13, 1946·Journal of the American Medical Association·W DOCK

Related Concepts

Arteriosclerosis
Blood Platelets
Blood Vessel
Sudden Death
Hemodynamics
Lipoproteins
Muscle, Smooth, Vascular
Myocardial Infarction
Prostaglandins

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

© 2021 Meta ULC. All rights reserved