Role of pollen NAD(P)H oxidase in allergic inflammation

Current Opinion in Allergy and Clinical Immunology
Nilesh DharajiyaSanjiv Sur

Abstract

Plant pollens are one of the most common outdoor allergens. Pollen grains and subpollen particles can reach lower airways and induce symptoms of seasonal asthma and allergic rhinitis. Plants possess NAD(P)H oxidase activity that generates reactive oxygen species for physiological functions such as root-hair and pollen-tube growth, defense against microbial infections and cell signaling. The presence of NAD(P)H oxidases in pollens and their role in induction of airway inflammation have not been described until recently. We discovered the presence of NAD(P)H oxidase in ragweed and other plant pollens. These oxidases induce reactive oxygen species in mucosal cells (signal 1) independent of adaptive immunity. This reactive oxygen species facilitates antigen (signal 2)-induced allergic inflammation. Inhibiting signal 1 by administration of antioxidants attenuated ragweed extract-induced allergic inflammation. Likewise, abrogating signal 2 by antigen challenge in mice lacking T cells failed to induce allergic inflammation. Reactive oxygen species generated by pollen NAD(P)H oxidase play a major role in pathogenesis of allergic airway inflammation and airway hypersensitivity. Based on our findings, we propose a 'two signal hypothesis ...Continue Reading

References

Sep 1, 1992·The American Journal of Physiology·R A KhalilK G Morgan
Sep 1, 1981·Respiration Physiology·R M StewartD E Niewoehner
Mar 1, 1995·American Journal of Respiratory Cell and Molecular Biology·G BrusselleR Pauwels
Jan 15, 1994·Lancet·S A KharitonovP J Barnes
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·A R HulsmannJ C de Jongste
Feb 25, 1996·Developmental Biology·E S PiersonP K Hepler
May 1, 1996·American Journal of Respiratory and Critical Care Medicine·G Sadeghi-HashjinF P Nijkamp
Feb 12, 1998·Plant Molecular Biology·M Tadege, C Kuhlemeier
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·P MontuschiP J Barnes
Oct 16, 1999·The Journal of Allergy and Clinical Immunology·D A KaminskyY Janssen
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·T HanazawaP J Barnes
Jan 13, 2001·Current Opinion in Immunology·S Gallucci, P Matzinger
Apr 3, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Peter WaynePaul Epstein
Jun 1, 2002·Science·A H Fitter, R S R Fitter
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·William J PerkinsKeith A Jones
Oct 2, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A FogartyJ Britton
Jul 31, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hyuek Jong LeeGou Young Koh
Sep 24, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yong Chul LeeUh-Hyun Kim
Apr 2, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ahmed NadeemSunil K Chhabra
Aug 3, 2005·The Journal of Clinical Investigation·Istvan BoldoghSanjiv Sur
Oct 8, 2005·International Archives of Allergy and Immunology·L K EllertsenG Hetland
Feb 24, 2006·International Archives of Allergy and Immunology·A C MottaG Lacroix
Jun 9, 2006·Environmental Health Perspectives·Christine A RogersFakhri A Bazzaz
Oct 13, 2006·The Journal of Allergy and Clinical Immunology·Attila BacsiIstvan Boldogh
Oct 17, 2006·Plant Physiology·Luis CárdenasPeter K Hepler
Dec 13, 2006·European Journal of Pharmacology·Katsuyuki KojimaKaoru Shimokata
Jan 26, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J A DunstanS L Prescott
Feb 6, 2007·Immunology and Allergy Clinics of North America·Nilesh G DharajiyaSanjiv Sur
May 17, 2007·The New Phytologist·Martin PotockýViktor Žárský

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Citations

Nov 26, 2009·Current Opinion in Allergy and Clinical Immunology·Melinda Braskett, Marc A Riedl
Nov 8, 2011·Respiratory Research·Umesh C S YadavSatish K Srivastava
Dec 14, 2011·Journal of Occupational and Environmental Medicine·Anthony M Szema
Sep 21, 2012·Acta Crystallographica. Section D, Biological Crystallography·Tse-Hao HuangShwu-Huey Liaw
Oct 15, 2019·Frontiers in Plant Science·María José Jimenez-QuesadaJuan de Dios Alché
Nov 24, 2011·Optics Express·Denis KiselevJean-Pierre Wolf
Jan 29, 2016·TheScientificWorldJournal·Hélène SénéchalJean-Pierre Sutra
Jun 20, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Rosa CodinaRichard F Lockey
Dec 30, 2008·Pharmacology & Therapeutics·Jennifer M RollandRobyn E O'Hehir
Dec 23, 2009·Current Opinion in Allergy and Clinical Immunology

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