Role of polydopamine's redox-activity on its pro-oxidant, radical-scavenging, and antimicrobial activities

Acta Biomaterialia
Huan LiuChangsheng Liu

Abstract

Polydopamine (PDA) is a bioinspired material and coating that offers diverse functional activities (e.g., photothermal, antioxidant, and antimicrobial) for a broad range of applications. Although PDA is reported to be redox active, the association between PDA's redox state and its functional performance has been difficult to discern because of PDA's complex structure and limitations in methods to characterize redox-based functions. Here, we use an electrochemical reverse engineering approach to confirm that PDA is redox-active and can repeatedly accept and donate electrons. We observed that the electron-donating ability of PDA offers the detrimental pro-oxidant effect of donating electrons to O2 to generate reactive oxygen species (ROS) or, alternatively, the beneficial antioxidant effect of quenching oxidative free radicals. Importantly, PDA's electron-donating ability depends on its redox state and is strongly influenced by external factors including metal ion binding as well as near-infrared (NIR) irradiation. Furthermore, we demonstrated that PDA possesses redox state-dependent antimicrobial properties in vitro and in vivo. We envision that clarification of PDA's redox activity will enable better understanding of PDA's cont...Continue Reading

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