PMID: 16617732Apr 19, 2006Paper

Role of polymorphonuclear leukocytes in development vascular complications in diabetes

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Krzysztof Mastej, Rajmund Adamiec

Abstract

Polymorphonuclear leukocytes (PMN) play role in the development of diabetic vascular complications. Activation PMN is associated with increased expression of adhesion molecules on the surface those cells. The aim of this study was to evaluate the expression of the beta2-integrin (CD11b/CD18) and selectin-L (CD 62l) on the surface of the peripheral blood polymorphonuclear leukocytes in type 2 diabetes with vascular complications. The study was performed in a group of 36 type 2 diabetic patients that were subdivided into three groups: group A (n = 12, mean 56+/-5 years) - diabetes with early nephropathy (microangiopathy), group B (n = 12, mean 55+/-4 years) - diabetes with macroangiopathy, group C (n = 12, mean 56+/-4 years) - diabetes without vascular complications. Healthy individuals (n = 13, 54+/-5 years) who agreed to participate in the study served as controls. The expression of the CD11b antigen and CD62L antigen on the surface of the polymorphonuclear leukocytes was measured by flow cytometry. There was a significant increase in the expression of the CD11b antigen on the surface of the peripheral blood polymorphonuclear leukocytes from diabetic patient with early nephropathy (group A), when compared with healthy controls ...Continue Reading

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