PMID: 6400565Apr 1, 1983Paper

Role of polypeptide growth factors in normal and abnormal growth

Kidney International
L M Patt, J C Houck

Abstract

In the preceding sections we have shown evidence that growth-promoting factors are involved in three basic situations. In normal embryonic development and function of mature organisms, growth factors such as NGF and EGF are of prime importance in supporting the necessary embryonic cell proliferation and the development of specific cell types. Other factors operate on subsets of mature cells during specialized functions such as inflammation. Included in this set would be factors such as CSF/MGF and Interleukin-2. Another basic function of growth factors has been shown to be wound repair and organ regeneration. This includes the well characterized PDGF and FGF as well as the various renotropic factors and liver growth factors. As these factors must operate in mature organisms with many different cell types and similar cell types in many locations, more specificity is needed than in embryonic growth. This has resulted in the organ specific factors such as the renotropins and in the unique delivery system of the PDGF. The recent discovery and characterization of the transforming growth factors has provided a possible connection between embryonic and normal developmental growth and the rapid cellular proliferation characteristic of ...Continue Reading

References

Jan 1, 1976·Cellular Immunology·B H Waksman, Y Namba
Jan 1, 1978·Annual Review of Biochemistry·R A Bradshaw
Jan 20, 1979·Lancet·T E StarzlG Mazzoni
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P D Gorin, E M Johnson
Jul 1, 1978·Hoppe-Seyler's Zeitschrift für physiologische Chemie·R Maschler, H R Maurer
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J E de Larco, G J Todaro
Jan 1, 1979·Journal of Supramolecular Structure·C F FoxR Vale
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A VogelR Ross
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H N AntoniadesC D Stiles
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C H HeldinA Wasteson
Sep 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·R K ShadduckE Gerard
Oct 3, 1977·Advances in Enzyme Regulation·N L BucherS Cohen
Oct 1, 1978·The Journal of Experimental Medicine·S GillisK A Smith
Dec 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·E J FeldmanM I Grossman
Feb 1, 1979·Pediatric Research·W Z CattertonM T Stahlman
May 1, 1979·Experimental Eye Research·D GospodarowiczT K Thakral
Aug 10, 1979·Biochimica Et Biophysica Acta·C D ScherC D Stiles
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·H N Antoniades, C D Scher
Jun 28, 1979·Nature·J M HutsonR Fowler
Jul 1, 1979·Inflammation·Y NaumJ C Houck
Sep 1, 1979·British Journal of Cancer·J B WeissP Phillips
Mar 1, 1979·Experimental Cell Research·B R McAuslan, H Hoffman
Aug 19, 1976·The New England Journal of Medicine·R Ross, J A Glomset
Jan 1, 1976·Annual Review of Biochemistry·D Gospodarowicz, J S Moran
Aug 12, 1976·The New England Journal of Medicine·R Ross, J A Glomset
Jul 15, 1977·Biochimica Et Biophysica Acta·C G Morley, J L Boyer
Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S Cohen, G Carpenter
May 1, 1975·The Medical Clinics of North America·H G Preuss, H Goldin
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R RossL Harker
Jun 26, 1969·The New England Journal of Medicine·R A Malt
Nov 28, 1973·Nature: New Biology·J C HouckR F Cheng
Feb 1, 1971·The Journal of Experimental Medicine·J FolkmanG Williams

❮ Previous
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Citations

Sep 23, 2006·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M GulumianJ Murray
Feb 1, 1996·Plastic and Reconstructive Surgery·G H Rudkin, T A Miller
Jan 1, 1988·Experimental Lung Research·D E Rannels, S R Rannels
Jul 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D A Kujubu, L G Fine
Mar 1, 1991·Kidney International·G Wolf, E G Neilson
Jun 22, 2005·Neoplasia : an International Journal for Oncology Research·Sophia RanMichael G Rosenblum
Jul 6, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Chitrangada AcharyaDominik R Haudenschild
Apr 1, 1992·The Annals of Otology, Rhinology, and Laryngology·D B Hom, R H Maisel
May 1, 1985·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·E D AvnerD Ellis
Jan 1, 1991·The Journal of Urology·L H KlotzG Mills
Oct 1, 1988·The American Journal of Physiology·D A GrosenbaughJ D Williams
Apr 15, 1988·Biochemical and Biophysical Research Communications·C CarameloR W Schrier

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