PMID: 22329010Feb 14, 2012Paper

Role of positron emission tomography-computed tomography in predicting survival after neoadjuvant chemotherapy and surgery for oesophageal adenocarcinoma

The British Journal of Surgery
R S GilliesF V Gleeson

Abstract

Positron emission tomography combined with computed tomography (PET-CT) is increasingly being used in the staging of oesophageal cancer. Some recent reports suggest it may be used to predict survival. None of these studies, however, reported on the prognostic value of PET-CT performed before neoadjuvant chemotherapy and surgery. The aim of this study was to determine whether pretreatment PET-CT could predict survival. Consecutive patients with oesophageal adenocarcinoma who underwent PET-CT before neoadjuvant chemotherapy and resection were included. Maximum standardized uptake value (SUV(max)), fluorodeoxyglucose (FDG)-avid tumour length and the presence of FDG-avid local lymph nodes were determined for all patients. Kaplan-Meier survival analysis was performed and multivariable analysis used to identify independent prognostic factors. A total of 121 patients were included (mean age 63 years, 97 men) of whom 103 underwent surgical resection. On an intention-to-treat basis, overall survival was significantly worse in patients with FDG-avid local lymph nodes (P < 0·001). SUV(max) and FDG-avid tumour length did not predict survival (P = 0·276 and P = 0·713 respectively). The presence of FDG-avid local lymph nodes was an independe...Continue Reading

References

Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A WeberU Fink
Jun 7, 2002·Lancet·UNKNOWN Medical Research Council Oesophageal Cancer Working Group
Aug 19, 2003·Seminars in Surgical Oncology·Leslie H Sobin
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hinrich A WiederWolfgang A Weber
Jul 23, 2005·AJR. American Journal of Roentgenology·Henderik L van WestreenenPieter L Jager
Jul 11, 2006·The New England Journal of Medicine·David Cunningham MAGIC Trial Participants
Sep 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katja OttJörg-Rüdiger Siewert
Jan 24, 2008·British Journal of Cancer·E P M van VlietP D Siersema
Feb 19, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J ShenfineB M Smithers
Jul 23, 2009·Annals of the Royal College of Surgeons of England·Tom CrosbyNicholas D Maynard
Sep 8, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·R S GilliesN D Maynard

❮ Previous
Next ❯

Citations

Jan 9, 2013·Nature Reviews. Gastroenterology & Hepatology·Michael SchweigertHubert J Stein
Jun 9, 2015·PET Clinics·Mie Holm Vilstrup, Drew A Torigian
Sep 26, 2013·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·W Phillip Law, Kenneth A Miles
Apr 10, 2013·World Journal of Surgery·Naoimh J O'FarrellDermot O'Toole
Jan 13, 2015·Langenbeck's Archives of Surgery·Kirsten LindnerRichard Hummel
Jun 3, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·W-K YapT-M Hung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.