Role of postnatal acquisition of the intestinal microbiome in the early development of immune function.

Journal of Pediatric Gastroenterology and Nutrition
Reed A DimmittRobin G Lorenz

Abstract

Therapy with broad-spectrum antibiotics is a common practice for premature infants. This treatment can reduce the biodiversity of the fecal microbiota and may be a factor in the cause of necrotizing enterocolitis. In contrast, probiotic treatment of premature infants reduces the incidence of necrotizing enterocolitis. We hypothesized that 1 mechanism for these observations is the influence of bacteria on postnatal development of the mucosal immune system. Expression of immune molecules and microbial sensors was investigated in the postnatal mouse gastrointestinal tract by real-time polymerase chain reaction. Subsequently, 2-week-old specific pathogen-free and microbial-reduced (MR; antibiotic treated) mice were compared for immune molecule and microbial sensor expression, mesenteric lymph node T-cell numbers and activation, intestinal barrier function/permeability, systemic lymphocyte numbers, and T-cell phenotype commitment. Toll-like receptor 2, 4, and 5 expression was highest in 2-week-old specific pathogen-free mice, and this expression was decreased in MR mice. There was no difference in intestinal tight-junctional function, as evaluated by fluorescein isothiocyanate-dextran uptake, but MR mice had increased bacterial tran...Continue Reading

References

May 1, 1995·The Pediatric Infectious Disease Journal·L LeighJ McGowan
Apr 6, 2000·European Journal of Gastroenterology & Hepatology·W HansW Falk
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rodney D NewberryRobin G Lorenz
Jun 11, 2002·Annual Review of Nutrition·Lora V HooperJeffrey I Gordon
Oct 17, 2003·The Journal of Clinical Investigation·Jie FanAsrar B Malik
Nov 26, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ximing ZhouAsrar B Malik
Feb 1, 2005·Annals of the New York Academy of Sciences·Andrew J Macpherson, Therese Uhr
Feb 25, 2005·Journal of Leukocyte Biology·Lisa C ParkerIan Sabroe
Mar 26, 2005·Science·Fredrik BäckhedJeffrey I Gordon
May 10, 2005·The British Journal of Nutrition·Maria Luisa Forchielli, W Allan Walker
Jul 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ruth E LeyJeffrey I Gordon
Aug 9, 2005·Seminars in Pediatric Surgery·Josef NeuElizabeth Beierle
Jan 19, 2006·The Journal of Experimental Medicine·Junya MasumotoNaohiro Inohara
Feb 17, 2006·Nature Immunology·Leonore A Herzenberg, James W Tung
Feb 17, 2006·Nature Immunology·John Trowsdale, Alexander G Betz
Mar 7, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emmanuel LeBouderMario O Labéta
Apr 12, 2006·The Journal of Experimental Medicine·Michael LotzMathias W Hornef
Jan 11, 2007·Pediatric Research·David S Newburg, W Allan Walker
Apr 26, 2007·Nature Reviews. Immunology·Ofer Levy
May 15, 2007·Seminars in Immunology·Andrew J MacphersonKathy D McCoy
Jun 6, 2007·Journal of Comparative Pathology·B MoreinK Hu
Oct 2, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Charles J AprahamianReed A Dimmit
Nov 22, 2007·Journal of Pediatric Gastroenterology and Nutrition·Andrew R BarclayDavid C Wilson
Nov 27, 2007·The Journal of Allergy and Clinical Immunology·Jean-Pierre AllamNatalija Novak
Jan 17, 2008·Molecular Systems Biology·Francois-Pierre J MartinJeremy K Nicholson
Feb 7, 2008·The Cochrane Database of Systematic Reviews·K Alfaleh, D Bassler
Sep 16, 2008·Journal of Microbiological Methods·Louise A O'SullivanAndrew J Weightman
Dec 11, 2008·Inflammatory Bowel Diseases·Elizabeth M StaleyRobin G Lorenz

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Citations

May 9, 2012·Archives of Disease in Childhood. Fetal and Neonatal Edition·Juliette C MadanPatricia L Hibberd
Apr 6, 2012·PloS One·Camilla Hartmann Friis HansenAxel Kornerup Hansen
Feb 5, 2013·Current Rheumatology Reports·Nigel YeohSimon Stebbings
Dec 2, 2014·Pathogens·M Pilar Francino
Jun 8, 2011·Clinics in Perinatology·Josef Neu, Jona Rushing
Dec 3, 2014·The American Journal of Pathology·Scott M TannerColin A Martin
Sep 28, 2012·Journal of Clinical Pharmacy and Therapeutics·A Li-Wan-Po
Nov 26, 2015·Clinics in Perinatology·Gloria S Pryhuber
Feb 2, 2015·Psychoneuroendocrinology·Maartje A C ZijlmansCarolina de Weerth
Dec 16, 2017·American Journal of Reproductive Immunology : AJRI·Shelley M LawrenceJames L Wynn
Jul 2, 2018·Developmental Psychobiology·Christine HechlerCarolina de Weerth
Sep 19, 2017·Probiotics and Antimicrobial Proteins·Banafsheh Douzandeh-Mobarrez, Ashraf Kariminik
Jun 2, 2015·Microbial Ecology in Health and Disease·Siddhartha MandalShyamal D Peddada
Jul 12, 2017·Stress : the International Journal on the Biology of Stress·Maartje A C ZijlmansCarolina de Weerth
Apr 20, 2019·Frontiers in Cellular and Infection Microbiology·Jannie G E HenderickxClara Belzer
Feb 8, 2020·Neuroscience·Francesca CirulliAlessandra Berry
Oct 4, 2020·The European Respiratory Journal·Peter M MouraniUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Resear
Jan 24, 2014·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Kyle J WolfRobin G Lorenz

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