Role of potassium and calcium in the generation of cellular bursts in the dentate gyrus

Journal of Neurophysiology
E Pan, J L Stringer

Abstract

Epileptiform activity, which appears to be endogenous, has been recorded in the granule cells of the dentate gyrus before the onset of synchronized seizure activity and has been termed cellular bursts. It has been postulated that an increase in input to the dentate gyrus causes a local increase in extracellular K+ concentration ([K+]o) and a decrease in [Ca2+]o that results in this cellular bursting. The first test of this hypothesis is to determine whether the cellular bursts appear in ionic conditions that occur in vivo before the onset of synchronized epileptic activity. This hypothesis was tested in vitro by varying the ionic concentrations in the perfusing solution and recording changes in the granule cells of the dentate gyrus. Intra- and extracellular recordings were made in the dentate gyri of hippocampal slices prepared from anesthetized adult Sprague-Dawley rats. Increasing the extracellular potassium or decreasing the extracellular calcium of the perfusing solution caused three forms of spontaneous activity to appear: depolarizing potentials, action potentials, and cellular bursts. Increasing potassium or decreasing calcium also caused the granule cells to depolarize and reduced their input resistance. No synchronize...Continue Reading

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Citations

Jul 12, 2008·Epilepsia·Sofiane BoucettaIgor Timofeev
Aug 10, 2011·Journal of Biological Physics·Gregory FilatovMaxim Bazhenov
Dec 12, 2019·Neural Regeneration Research·Fushun WangJason H Huang
Apr 2, 2004·Journal of Neurophysiology·M BazhenovT J Sejnowski
Oct 28, 2011·Journal of Neurophysiology·Dmytro IsaevOleksandr Maximyuk
Jan 24, 2007·Journal of Neuroscience Research·Marita BrobergJohn O Willoughby
Nov 9, 2000·Journal of Neurophysiology·J L HardisonJ V Nadler
Sep 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Vladislav VolmanTerrence J Sejnowski
Sep 4, 2015·Physical Biology·Antônio Márcio RodriguesAntônio-Carlos Guimarães de Almeida
Oct 10, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Flavio Fröhlich, Maxim Bazhenov

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