Role of potassium in hypokalemia-induced hyponatremia: lessons learned from the Edelman equation

Clinical and Experimental Nephrology
Minhtri K Nguyen, Ira Kurtz

Abstract

It is well known that changes in the mass balance of K+ can lead to an alteration in the plasma water sodium concentration ([Na+]pw). We have recently shown that based on the Edelman equation, the [Na+]pw is determined by the total exchangeable Na+ (Nae), total exchangeable K+ (Ke), total body water (TBW), osmotically inactive Nae and Ke, plasma water [K+], intracellular and extracellular osmotically active non-Na+ and non-K+ osmoles, and plasma osmotically active non-Na+ and non-K+ osmoles. In light of these findings, a re-analysis of the role of K+ in modulating the [Na+]pw is required in understanding the pathophysiology of hypokalemia-induced hyponatremia. In this article, we characterize the complex role of K+ in the pathogenesis of hypokalemia-induced hyponatremia using a three-compartment model and the known parameters in the Edelman equation. Our analysis indicates that K+ modulates the [Na+]pw by changing Ke in addition to the parameters in the y-intercept of the Edelman equation. Moreover, the magnitude of potassium-induced changes in the [Na+]pw is determined by the pathophysiologic mechanisms by which changes in Ke occur.

Citations

Dec 3, 2010·Seminars in Dialysis·Ron Zanger
Aug 28, 2014·The American Journal of the Medical Sciences·Kamel A GharaibehTibor Fülöp
Aug 13, 2011·The Journal of Infection·George LiamisMoses Elisaf
Jul 31, 2013·Journal of Critical Care·Sandra StieglmairChristoph Schwarz
Mar 27, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tomas Berl, Asghar Rastegar
Jun 16, 2009·Seminars in Nephrology·Richard H SternsJohn Kevin Hix
Aug 2, 2016·Clinical Kidney Journal·Ramy Magdy HannaJames Wilson
Jul 24, 2004·American Journal of Physiology. Renal Physiology·Minhtri K Nguyen, Ira Kurtz
Sep 24, 2004·American Journal of Physiology. Renal Physiology·Minhtri K Nguyen, Ira Kurtz
Dec 31, 2004·American Journal of Physiology. Renal Physiology·Minhtri K Nguyen, Ira Kurtz
May 28, 2014·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Yijuan SunAntonios H Tzamaloukas
Aug 19, 2017·Case Reports in Nephrology·Thaofiq IjaiyaKameswari Lakshmi
Jul 5, 2017·Current Heart Failure Reports·Ahmed Elfar, Kamalanathan K Sambandam
Jul 9, 2021·Journal of Community Hospital Internal Medicine Perspectives·Abdurrahman HamadahKamel Gharaibeh

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