Role of Prefrontal Persistent Activity in Working Memory

Frontiers in Systems Neuroscience
Mitchell R Riley, Christos Constantinidis

Abstract

The prefrontal cortex is activated during working memory, as evidenced by fMRI results in human studies and neurophysiological recordings in animal models. Persistent activity during the delay period of working memory tasks, after the offset of stimuli that subjects are required to remember, has traditionally been thought of as the neural correlate of working memory. In the last few years several findings have cast doubt on the role of this activity. By some accounts, activity in other brain areas, such as the primary visual and posterior parietal cortex, is a better predictor of information maintained in visual working memory and working memory performance; dynamic patterns of activity may convey information without requiring persistent activity at all; and prefrontal neurons may be ill-suited to represent non-spatial information about the features and identity of remembered stimuli. Alternative interpretations about the role of the prefrontal cortex have thus been suggested, such as that it provides a top-down control of information represented in other brain areas, rather than maintaining a working memory trace itself. Here we review evidence for and against the role of prefrontal persistent activity, with a focus on visual ...Continue Reading

References

Jan 31, 1992·Science·A Baddeley
Jul 1, 1988·The Journal of Comparative Neurology·M Petrides, D N Pandya
Feb 1, 1989·Journal of Neurophysiology·S FunahashiP S Goldman-Rakic
May 1, 1971·Journal of Neurophysiology·K Kubota, H Niki
Aug 13, 1971·Science·J M Fuster, G E Alexander
Aug 1, 1994·Journal of Neurophysiology·M A SteinmetzJ R McLaughlin
Dec 15, 1993·The Journal of Comparative Neurology·J B LevittJ S Lund
Jan 1, 1993·Somatosensory & Motor Research·G di Pellegrino, S P Wise
Jun 17, 1993·Nature·J JonidesM A Mintun
Aug 14, 1995·The Journal of Comparative Neurology·M F Kritzer, P S Goldman-Rakic
Aug 1, 1996·Journal of Neurophysiology·C Constantinidis, M A Steinmetz
Nov 5, 1997·Experimental Brain Research·M A Sommer, E J Tehovnik
Nov 14, 1997·Science·S P O ScalaidheP S Goldman-Rakic
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·L G UngerleiderJ V Haxby
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·A M OwenM Petrides
Jun 26, 1999·Experimental Brain Research·I M White, S P Wise
Mar 11, 2000·Journal of Neurophysiology·D DurstewitzT J Sejnowski
Feb 27, 2001·Nature Neuroscience·C ConstantinidisP S Goldman-Rakic
Apr 3, 2001·Annual Review of Neuroscience·E K Miller, J D Cohen
Jun 22, 2001·Nature·J D WallisE K Miller
Jul 31, 2001·Trends in Neurosciences·X J Wang
Aug 17, 2001·Journal of Cognitive Neuroscience·C MarshuetzT L Chenevert

❮ Previous
Next ❯

Citations

May 27, 2016·Nature Reviews. Neuroscience·Christos Constantinidis, Torkel Klingberg
Aug 22, 2016·NeuroImage·Tobias Katus, Martin Eimer
Mar 3, 2017·Journal of Cognitive Neuroscience·Amanda E van Lamsweerde, Jeffrey S Johnson
May 26, 2017·Nature Neuroscience·Rosanne L Rademaker, John T Serences
Mar 10, 2017·Proceedings of the National Academy of Sciences of the United States of America·Matthew L LeavittJulio C Martinez-Trujillo
Jan 9, 2017·Trends in Cognitive Sciences·Thomas B ChristophelJohn-Dylan Haynes
Feb 24, 2017·Journal of Neurophysiology·Xin Zhou, Christos Constantinidis
Nov 9, 2016·Nature Communications·Xin ZhouChristos Constantinidis
Aug 14, 2019·Annals of the New York Academy of Sciences·Jan Kamiński, Ueli Rutishauser
Sep 13, 2018·Journal of Neurophysiology·Ethan M Meyers
Jun 28, 2018·Journal of Neurophysiology·Dominic Standage, Martin Paré
Jul 3, 2016·Cerebral Cortex·Mitchell R RileyChristos Constantinidis
May 10, 2018·Frontiers in Cellular Neuroscience·Przemysław KurowskiPaweł Szulczyk
May 16, 2019·Stress : the International Journal on the Biology of Stress·Enrique Francisco MaldonadoSilvia García
Jun 13, 2020·Frontiers in Neural Circuits·Sihai LiXue-Lian Qi
Sep 19, 2018·Nature Communications·Mitchell R RileyChristos Constantinidis
Oct 12, 2017·Frontiers in Neuroscience·Hua TangChristos Constantinidis
Jan 30, 2018·Frontiers in Neural Circuits·Camila S DeolindoRenan C Moioli
Aug 23, 2018·Frontiers in Integrative Neuroscience·Christos Constantinidis, Xue-Lian Qi
Jul 3, 2018·Nature Human Behaviour·Matar HallerAvgusta Y Shestyuk
Apr 2, 2019·Frontiers in Cellular Neuroscience·Jesse J Langille
Aug 23, 2018·Frontiers in Human Neuroscience·Yi-Li TsengGuan-Yi Lu
Mar 17, 2019·Proceedings of the National Academy of Sciences of the United States of America·Hua TangChristos Constantinidis
Sep 2, 2020·Epilepsy & Behavior : E&B·Tyler E GastonUNKNOWN UAB CBD Program
Jan 6, 2021·Trends in Cognitive Sciences·Elizabeth S LorencJarrod A Lewis-Peacock
Nov 4, 2020·Scientific Reports·Dong-Hyun LimMin Whan Jung
Apr 7, 2021·Nature Neuroscience·Alexandra Libby, Timothy J Buschman
Aug 3, 2021·Journal of Alzheimer's Disease : JAD·Saravanan SubramaniamChristos Constantinidis
Aug 10, 2021·Frontiers in Neural Circuits·Clayton E Curtis, Thomas C Sprague
Sep 16, 2021·PLoS Computational Biology·Elham Ghazizadeh, ShiNung Ching

❮ Previous
Next ❯

Software Mentioned

Multi Pattern Analysis ( MVPA )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.