Role of prelimbic cortex PKC and PKMζ in fear memory reconsolidation and persistence following reactivation.

Scientific Reports
Thiago Rodrigues da SilvaCristina A Stern

Abstract

The persistence of newly acquired memories is supported by the activity of PKMζ, an atypical isoform of protein kinase C (PKC). Whether the activity of conventional and atypical PKC isoforms contributes to reactivated memories to persist is still unknown. Similarly, whether memory reactivation is a prerequisite for interventions to be able to change memory persistence is scarcely investigated. Based on the above, we examined the role of conventional and atypical PKC isoforms in the prelimbic cortex in reconsolidation and persistence of a reactivated contextual fear memory in male Wistar rats. It is shown that (i) inhibiting the PKC activity with chelerythrine or the PKMζ activity with ZIP impaired the persistence of a reactivated memory for at least 21 days; (ii) ZIP given immediately after memory reactivation affected neither the reconsolidation nor the persistence process. In contrast, when given 1 h later, it impaired the memory persistence; (iii) chelerythrine given immediately after memory reactivation impaired the reconsolidation; (iv) omitting memory reactivation prevented the chelerythrine- and ZIP-induced effects: (v) the ZIP action is independent of the time elapsed between its administration and the initial memory te...Continue Reading

References

Mar 1, 1969·Journal of Comparative and Physiological Psychology·R J Blanchard, D C Blanchard
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T C SacktorE Sublette
Apr 1, 1996·Current Opinion in Cell Biology·S Jaken
Mar 1, 1997·Behavioural Brain Research·J Przybyslawski, S J Sara
Mar 27, 2002·Nature Neuroscience·Douglas S F LingTodd C Sacktor
Mar 27, 2002·Nature Neuroscience·Eric A DrierJerry C P Yin
Oct 22, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sevil Duvarci, Karim Nader
Aug 26, 2006·Science·Eva PastalkovaTodd Charlton Sacktor
Jul 29, 2009·Behavioral Neuroscience·Janine L KwapisFred J Helmstetter
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Cynthia KatcheJorge H Medina
Dec 2, 2010·Nature Reviews. Neuroscience·Todd C Sacktor
Jan 25, 2011·Nature Neuroscience·Ryan G Parsons, Michael Davis
Apr 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Diancai CaiDavid L Glanzman
May 3, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cristina A J SternLeandro J Bertoglio
Feb 6, 2013·Behavioural Brain Research·Fabricio H Do MonteAntonio de Padua Carobrez
May 21, 2013·Learning & Memory·Daisuke NakayamaHiroshi Nomura
Sep 18, 2013·Learning & Memory·Karl Peter Giese, Keiko Mizuno
Jan 16, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daisuke NakayamaHiroshi Nomura
Feb 13, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joëlle LopezKarim Nader
Mar 25, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Cristina A J SternLeandro J Bertoglio
Aug 14, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yan-Xue XueLin Lu
Dec 17, 2015·Learning & Memory·Bruna Amanda GirardiMaribel Antonello Rubin
Jun 21, 2016·Neurobiology of Learning and Memory·M C KrawczykM M Boccia
Jun 21, 2016·Neurobiology of Learning and Memory·Hyoung-Gon KoBong-Kiun Kaang
Aug 25, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Thiago R da SilvaCristina A J Stern
Dec 6, 2016·Learning & Memory·Chicora F OliverChristoph Wiedenmayer
Jun 26, 2017·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Natali LevinIrit Akirav
Nov 16, 2017·Science Signaling·Todd Charlton Sacktor, Johannes W Hell
Jan 10, 2019·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Janine I RossatoMartín Cammarota

❮ Previous
Next ❯

Citations

Feb 9, 2021·Reviews in the Neurosciences·Hamish Patel, Reza Zamani

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The European Journal of Neuroscience
Natalia V BalPavel M Balaban
Learning & Memory
Xavier De JaegerPascal Roullet
The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Chuljung KwakBong-Kiun Kaang
© 2021 Meta ULC. All rights reserved