Abstract
The cardiovascular effects of sulfonylureas (SU) in diabetic patients are controversial and it has been suggested that diabetic patients with acute myocardial infarction while on SU were at increased risk. To assess the in-hospital outcome of patients with acute myocardial infarction according to the use of SU at the time of the acute episode. Of 443 intensive care units in France, 369 (83%) prospectively collected all cases of infarction admitted within 48 h of symptom onset in November 2000. Among the 2320 patients included in the registry, 487 (21%) had diabetes, of whom 215 (44%) were on SU. Patients on SU were older and had a more frequent history of hyperlipidemia than those not receiving SU. Type and location of infarction were similar in the two groups, and there was no difference in Killip class on admission. In-hospital mortality was lower in patients on SU (10.2%) than in those without SU (16.9%) (p = 0.035). There was a trend toward less frequent ventricular fibrillation (2.3% vs 5.9%, p = 0.052). In two models of multivariate analyses, SU therapy was associated with decreased in-hospital mortality (model 1: relative risk: 0.44, p = 0.012; model 2: relative risk: 0.37, p = 0.020). In this nationwide registry reflect...Continue Reading
References
Oct 1, 1991·Seminars in Thrombosis and Hemostasis·J Gram, J Jespersen
Sep 1, 1972·Diabetes·H S Seltzer
May 1, 1996·Neuron·N InagakiS Seino
Nov 1, 1996·Circulation·R L Engler, D M Yellon
Jan 1, 1997·The American Journal of Cardiology·S D Correa, S Schaefer
May 24, 1997·BMJ : British Medical Journal·K Malmberg
Jul 1, 1997·Circulation·J C ClevelandA H Harken
Dec 31, 1997·Journal of the American College of Cardiology·N DanchinJ P Cambou
Apr 30, 1998·Journal of the American College of Cardiology·P A Brady, A Terzic
Sep 3, 1998·Diabetes·F M GribbleF M Ashcroft
Feb 6, 1999·Journal of the American College of Cardiology·K N GarrattD R Holmes
Mar 19, 1999·European Heart Journal·F TomaiP A Gioffrè
Apr 23, 1999·European Heart Journal·H KlepzigW Burger
Jan 20, 2000·European Heart Journal·A KlamannM A Nauck
Jun 27, 2001·Circulation·M M MocanuD M Yellon
Aug 3, 2001·Diabetologia·C L LawrenceF M Ashcroft
Aug 29, 2001·The American Journal of Cardiology·W S Aronow, C Ahn
Sep 28, 2001·Diabetes·F ReimannF M Gribble
Dec 1, 2001·Journal of Thrombosis and Thrombolysis·A HalkinS Behar
Dec 26, 2001·Heart·T ReffelmannE R Schwarz
Mar 2, 2002·Diabetes·Roldano ScognamiglioAntonio Tiengo
Jul 16, 2002·Heart·N DanchinJ-P Cambou
Jan 31, 2003·The New England Journal of Medicine·Peter GaedeOluf Pedersen
Nov 18, 2004·Heart·G HananiaUNKNOWN USIC 2000 Investigators
Citations
Oct 1, 2008·Cardiovascular Drugs and Therapy·Yumei YeYochai Birnbaum
Sep 29, 2005·Current Diabetes Reports·George Dailey
Sep 20, 2011·Diabetes, Obesity & Metabolism·A S AbdelmoneimS H Simpson
Jun 12, 2010·Vascular Health and Risk Management·Magnus DenckerMozhgan Dorkhan
Aug 28, 2010·International Journal of Cardiology·C H JørgensenP R Hansen
Aug 21, 2007·Diabetes & Metabolism·M VirallyP-J Guillausseau
Sep 21, 2015·International Journal of Cardiology·Ahmed S AbdelmoneimScot H Simpson
Feb 19, 2014·Diabetes, Obesity & Metabolism·S E Holden, C J Currie
Jun 28, 2013·Diabetes, Obesity & Metabolism·A S AbdelmoneimS H Simpson
Feb 26, 2015·Diabetes, Obesity & Metabolism·A S AbdelmoneimS H Simpson
Jun 7, 2011·Expert Opinion on Pharmacotherapy·Thomas ForstAndreas Pfützner
Jul 7, 2012·European Journal of Pharmacology·Yige BaoWu Yang
Aug 26, 2014·Diabetes Care·William T CefaluMatthew C Riddle
Dec 6, 2008·La Presse médicale·Jean-Louis SchliengerBernard Goichot
Jun 19, 2019·Phytotherapy Research : PTR·Tao JiJin-Ao Duan
Jul 22, 2006·Journal of Cardiovascular Medicine·Ayman Ahmed El-Menyar
Apr 15, 2016·Journal of Cardiovascular Pharmacology·Giuseppe Biondi-ZoccaiFrancesco Nudi
Aug 13, 2010·The Journal of Clinical Endocrinology and Metabolism·Marianne ZellerUNKNOWN French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction investigators
May 22, 2009·Diabetes/metabolism Research and Reviews·Henriette T HorsdalJørgen Rungby
Apr 22, 2017·Diabetes Care·Laurent Azoulay, Samy Suissa