Role of procalcitonin use in the management of sepsis

Journal of Thoracic Disease
Claudia GregorianoPhilipp Schuetz

Abstract

Important aspects of sepsis management include early diagnosis as well as timely and specific treatment in the first few hours of triage. However, diagnosis and differentiation from non-infectious causes often cause uncertainties and potential time delays. Correct use of antibiotics still represents a major challenge, leading to increased risk for opportunistic infections, resistances to multiple antimicrobial agents and toxic side effects, which in turn increase mortality and healthcare costs. Optimized procedures for reliable diagnosis and management of antibiotic therapy has great potential to improve patient care. Herein, biomarkers have been shown to improve infection diagnosis, help in early risk stratification and provide prognostic information which helps optimizing therapeutic decisions ("antibiotic stewardship"). In this context, the use of the blood infection marker procalcitonin (PCT) has gained much attention. There is still no gold standard for the detection of sepsis and use of conventional diagnostic approaches are restricted by some limitations. Therefore, additional tests are necessary to enable early and reliable diagnosis. PCT has good discriminatory properties to differentiate between bacterial and viral in...Continue Reading

Citations

Jul 1, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Luisa AgnelloMarcello Ciaccio
Nov 20, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Luís CabralVera Afreixo
Feb 23, 2021·Current Infectious Disease Reports·Aaron J Heffernan, Kerina J Denny
Mar 30, 2021·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Sridhar MangaleshAjay Malik
Apr 23, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yin LiuShihong Zhang

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