PMID: 3747850Jul 1, 1986Paper

Role of progestogens in the prevention of breast cancer

Maturitas
R D Gambrell

Abstract

The incidence of breast cancer has continued to decrease each year at Wilford Hall United States Air Force Medical Center with the ever-increasing use of combined progestogen-oestrogen replacement therapy over the past 12 yr. By 1983, the overall incidence of breast cancer had fallen to 53.9:100 000. The lowest rate for the 9 yr of a prospective study to 1983 was seen among the oestrogen-progestogen users (66.8:100 000) although it was also slightly reduced in both the unopposed oestrogen users (142.3:100 000 and the oestrogen vaginal cream users (116.3:100 000). The incidence was significantly lower in both the oestrogen-progestogen users and the oestrogen users (P less than or equal to 0.01) as compared with untreated women (343.5:100 000). These data further strengthen the growing evidence that the addition of progestogen to oestrogen decreases the risk of mammary malignancy.

References

Aug 19, 1976·The New England Journal of Medicine·R HooverB MacMahon
Dec 1, 1983·The New England Journal of Medicine·G M ClarkJ S Marshall
Jan 28, 1983·JAMA : the Journal of the American Medical Association·E R González

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Citations

Sep 1, 1996·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·G BlumbergA Neri
Jan 1, 1993·Baillière's Clinical Endocrinology and Metabolism·T M Mack
May 1, 1987·American Journal of Obstetrics and Gynecology·R D Gambrell
Jun 1, 1992·American Journal of Obstetrics and Gynecology·R A Lobo
Oct 22, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Riccardo PonzonePiero Sismondi
Oct 26, 2005·Contraception·Johan BultenThom Dieben
Jul 1, 1989·British Journal of Obstetrics and Gynaecology·D FraserJ Pryse-Davies
Oct 1, 1988·Maturitas·R D Gambrell
Mar 8, 2007·Experimental Psychology·Jennifer H CoaneJ Scott Jordan
Mar 1, 1989·Postgraduate Medicine·A G Charles
Sep 29, 1998·The Journal of Pharmacy and Pharmacology·T B Vree, C J Timmer
Jul 1, 1986·Maturitas·R D Gambrell

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