Role of (pro)renin receptor in albumin overload-induced nephropathy in rats.

American Journal of Physiology. Renal Physiology
Hui FangTianxin Yang

Abstract

Proteinuria is not only a common feature of chronic kidney diseases (CKD) but also an independent risk factor promoting CKD progression to end-stage renal failure. However, the underlying molecular mechanisms for protein overload-induced renal injury remain elusive. The present study examined the role of (pro)renin receptor (PRR) in pathogenesis of albumin overload (AO)-induced nephropathy and activation of the intrarenal renin-angiotensin system (RAS) in rats. Wistar rats underwent unilateral nephrectomy and were treated for 7 wk with vehicle, bovine serum albumin (5 g·kg-1·day-1 via a single ip injection), alone or in conjunction with the PRR decoy inhibitor PRO20 (500 μg·kg-1·day-1 via 3 sc injections). The AO rat model exhibited severe proteinuria, tubular necrosis, and interstitial fibrosis, oxidative stress, and inflammation, accompanied by elevated urinary N-acetyl-β-d-glucosaminidase activity and urinary β2-microglobulin secretion, all of which were significantly attenuated by PRO20. Urinary and renal levels of renin, angiotensinogen, and ANG II were elevated by AO and suppressed by PRO20, contrasting to largely unaltered plasma levels of the RAS parameters. The AO model also showed increased renal expression of full-le...Continue Reading

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Citations

Jul 19, 2018·American Journal of Physiology. Renal Physiology·Kevin T YangJ David Symons
Jun 6, 2019·Nature Reviews. Nephrology·Atsuhiro Ichihara, Midori Sasaki Yatabe
Jan 21, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gertrude ArthurFrédérique B Yiannikouris
Jun 24, 2021·The Journal of Pharmacology and Experimental Therapeutics·Manman QinJun Yu

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Methods Mentioned

BETA
ELISA
Assay
PCR
reverse transcription-PCR

Software Mentioned

Pro Plus
Primer3
Image

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