PMID: 2493776Mar 1, 1989Paper

Role of prostacyclin in the splanchnic hyperemia contributing to portal hypertension

Annals of Surgery
J V SitzmannK Campbell

Abstract

To determine the possible role of prostacyclin (PGI2) as a mediator of the splanchnic hyperemia seen with portal hypertension, the portal and mesenteric hemodynamics in normal and portal hypertensive rabbits were studied before and after cyclo-oxygenase blockade. Three weeks after partial portal vein ligation, splenic pulp pressure was elevated from 4.3 +/- 0.9 to 9.8 +/- 0.8 mmHg (p less than 0.01). Mesenteric blood flow increased from 77.0 +/- 4.7 ml.min-1.100 g-1 to 99.1 +/- 5.19 ml/min-1/100 g-1. Mesenteric vascular resistance fell from 0.82 +/- 0.6 mmHg/ml-1/min-1 to 0.49 +/- 0.07 mmHg/ml-1/min-1 (p less than 0.01). These hemodynamic changes were associated with a 27.3 +/- 0.2% rise in systemic arterial levels of PGI2 (p less than 0.01) and were substantially ameliorated by cyclo-oxygenase blockade with indomethacin. The effects of indomethacin blockade were reversed by exogenous PGI2. Moreover, in normotensive rabbits, infusion of PGI2 reproduced the splanchnic hyperemia and caused a very small but significant increase in portosystemic shunting. These findings support the previously proposed concept that splanchnic hyperemia may contribute to the maintenance of chronic portal hypertension. Furthermore, they suggest that t...Continue Reading

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Citations

Sep 1, 1989·The Journal of Surgical Research·J V SitzmannP W Lin
Jan 16, 1995·European Journal of Pharmacology·P A CahillJ V Sitzmann
Mar 12, 1999·The Surgical Clinics of North America·V L ScottY Kang
Mar 23, 2000·Journal of Hepatology·J Bosch, J C García-Pagán
Feb 1, 1996·Journal of Hepatology·Y T HuangM C Yang
Oct 7, 2000·Journal of Gastroenterology and Hepatology·O F LaiS T Chan
Mar 1, 1993·Annals of Surgery·J V SitzmannJ L Cameron
Jun 1, 1994·The Journal of Clinical Investigation·P A CahillJ V Sitzmann
Jan 16, 2008·Journal of the Chinese Medical Association : JCMA·Hui-Chun HuangShou-Dong Lee
Nov 26, 2013·Clinics in Chest Medicine·Nadine Al-Naamani, Kari E Roberts
May 26, 2012·Gastroenterology·Juan Carlos Garcia-Pagán, Vijay H Shah
Feb 1, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hui-Chun HuangShou-Dong Lee
Apr 1, 1990·The Journal of Surgical Research·J V SitzmannG B Bulkley
Mar 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C Guarner, G Soriano
Sep 1, 1991·The Journal of Surgical Research·K A CampbellJ V Sitzmann
Mar 1, 1991·The Journal of Surgical Research·C W DunnM F Vuitch
Oct 10, 2006·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Norio NoguchiShigeki Arii
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M C HouJ V Sitzmann
Sep 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F ObertiD Lebrec
Sep 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M CasadevallB J Whittle
Dec 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y WuJ V Sitzmann
Nov 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W H Abelmann
Aug 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J V SitzmannR C Burns
Aug 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A CahillJ V Sitzmann
Jan 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M HendersonM H Kutner
Feb 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M HendersonM H Kutner
Jul 28, 2013·Journal of the Chinese Medical Association : JCMA·Ching-Chih ChangShou-Dong Lee
Nov 15, 2006·Scandinavian Journal of Gastroenterology·Hui-Chun HuangShou-Dong Lee
Jun 11, 2003·European Journal of Clinical Investigation·H-C HuangS-D Lee
May 1, 1996·Scandinavian Journal of Gastroenterology·L S ChenS D Lee
Mar 9, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Maria Teresa MelgosaJoan Albert Barberà
Mar 10, 1999·The American Journal of Physiology·J MuñozM Alvarez-Mon
Oct 1, 1992·Alimentary Pharmacology & Therapeutics·R D Grose, P C Hayes
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·M A PotenzaD Mitolo-Chieppa

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