PMID: 6964402Oct 1, 1982Paper

Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide

Proceedings of the National Academy of Sciences of the United States of America
R UenoO Hayaishi

Abstract

The intraperitoneal administration of lipopolysaccharide from Salmonella typhimurium (1 mg/kg) caused a fall in the rat colonic temperature of about 2 degrees C at an ambient temperature of 22 +/- 3 degrees C. The hypothermia induced by the lipopolysaccharide was abated in a dose-dependent manner by the administration of indomethacin. Other inhibitors of prostaglandin synthetase such as aspirin, flufenamic acid, and phenylbutazone had effects similar to those of indomethacin. When various prostaglandins were injected intracerebroventricularly, only prostaglandin D2 caused a dose-dependent fall in the colonic temperature at doses between 1.2 and 6 nmol/kg. Microinjection of prostaglandin D2 into the preoptic area caused hypothermia of about 1 degree C. However, injection of prostaglandin D2 into the posterior hypothalamus had little effect on the colonic temperature. The hypothermia caused by prostaglandin D2 was not abated by the administration of indomethacin. The amount of prostaglandin D2 increased significantly in the preoptic/hypothalamic region of rat brain 1 hr after the intraperitoneal administration of the lipopolysaccharide, whereas such increase was not observed in rats pretreated with indomethacin. The in vitro incu...Continue Reading

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Citations

Nov 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T SatoA Matsuki
Jun 15, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Samir S AyoubChristopher Bolton
Apr 23, 2009·Neurotoxicity Research·Sofiyan SaleemSylvain Doré
Feb 14, 1987·Biochimica Et Biophysica Acta·F SuzukiO Hayaishi
Feb 15, 1988·Biological Psychiatry·K OhishiO Hayaishi
Feb 1, 1988·Prostaglandins·R KawataO Mizukoshi
Mar 1, 1987·Pharmacology, Biochemistry, and Behavior·R SaitoN Ono
Jan 1, 1993·Progress in Lipid Research·M NegishiA Ichikawa
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Sep 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S ItoO Hayaishi
Feb 16, 1999·Biochimica Et Biophysica Acta·Y Urade, O Hayaishi
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Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·Y WatanabeO Hayaishi
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A YamashitaO Hayaishi
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R UenoO Hayaishi
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S InouéO Hayaishi
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