Role of prostaglandins in mediating differences in human internal mammary and radial artery relaxation elicited by hypoxia

The Journal of Pharmacology and Experimental Therapeutics
Sachin A GupteM S Wolin

Abstract

The effects of hypoxia-reoxygenation on internal mammary (IMA) and radial (RA) arteries used for coronary artery bypass grafting (CABG) were examined to identify mechanisms regulating contractile function and differences that could contribute to vasospasm. Isolated endothelium-intact IMA and RA rings precontracted with KCl (30 mM) rapidly dilated to hypoxia (95% N(2)/5% CO(2)) with a greater relaxation in RA than IMA. Inhibitors of cyclooxygenase (10 microM indomethacin) and the thromboxane A(2) (TxA)(2) receptor [1 microM [1S-[1alpha,2alpha(Z),3alpha,4alpha]]-7-[3-[2-(phenylamino)carbonyl]hydrazine]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid (SQ-29548)] potentiated the relaxation to hypoxia in IMA, but not RA, a response associated with increases in TxA(2). Relaxation of IMA and RA to hypoxia appears to involve a calcium-reuptake mechanism inhibited by cyclopiazonic acid (0.2 mM), and it was not attenuated by a blocker of potassium channels (10 mM TEA). The recovery of force generation of IMA, but not RA, upon reoxygenation after 30 min of hypoxia was significantly reduced in the initial phase of reoxygenation by indomethacin and SQ-29548 and by endothelin receptor blocker BQ-123 [cyclo(l-Leu-d-Trp-d-Asp-l-Pro-d-Val...Continue Reading

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Citations

Mar 5, 2008·Antioxidants & Redox Signaling·Sachin A Gupte, Michael S Wolin
May 15, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sukrutha ChettimadaSachin A Gupte
Jan 18, 2007·Fundamental & Clinical Pharmacology·Martin T R GrapowElse Müller-Schweinitzer
May 30, 2006·The Annals of Thoracic Surgery·Muhammad ArshadSachin A Gupte
May 23, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Rakhee GupteSachin A Gupte
Feb 21, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Igor V KizubSachin A Gupte
Jul 30, 2020·Prostaglandins & Other Lipid Mediators·Gulsev OzenGokce Topal

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