PMID: 6539941May 1, 1984Paper

Role of prostaglandins in the production of natriuretic factor by the isolated rat kidney

Renal Physiology
P Cambier, J P Godon

Abstract

The renal origin of natriuretic factor (NF) of high molecular weight (MW 45,000) has been previously demonstrated. Its role in the control of sodium excretion by the kidney has been strongly suggested. The aim of the present work was to study the relationship between NF and prostaglandins, which are known to modify the renal regulation of sodium. (1) The activity of NF, obtained by ultrafiltration and gel filtration from pooled plasma of salt-loaded rats, was tested on an isolated rat kidney perfused by a cell-free medium. A significant natriuresis was observed in the kidneys isolated either from normal rats or from indomethacin-pretreated rats after injection of NF. Moreover, a dose-response curve was obtained with increasing amounts of NF. (2) The ability of isolated rat kidney to produce NF was studied in two series of salt-deprived rats, the second series being pretreated with indomethacin. The production of NF by isolated kidneys was induced by addition of saline to the fluid perfusing kidneys isolated from normal or indomethacin-pretreated rats fed a salt-depleted diet. Before addition of saline, no natriuretic activity was detectable. After the addition of 0.9% NaCl, NF was only found in the perfusate from kidneys isolat...Continue Reading

Citations

Nov 1, 1985·Archives internationales de physiologie et de biochimie·A Chachati, J P Godon
Dec 14, 2007·IEEE Transactions on Bio-medical Engineering·Mahmoud El-Gohary, James McNames
Jan 13, 2006·IEEE Transactions on Bio-medical Engineering·Giuseppe BaselliMassimo Pagani
Dec 19, 2014·Frontiers in Endocrinology·John M Hamlyn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.