Role of prostaglandins in the reversal of one-kidney hypertension in the rabbit.

Circulation Research
J C RomeroC G Strong

Abstract

Hypertensive rabbits with a clip on the renal artery of their solitary remaining kidney show an abrupt decrease in blood pressure after the arterial constriction is released. Although the mechanism underlying this phenomenon remains controversial, some experimental evidence suggests that it could be humorally mediated. The involvement of prostaglandins was investigated by examining the effect of the release of the arterial constriction on blood pressure, renal blood flow, glomerular filtration rate, and urinary output in five conscious single-kidney hypertensive rabbits in which prostaglandin synthesis was blocked with indomethacin (priming intravenous injection of 9 mg/kg followed by a constant infusion of 1 mg/kg hour-1). The results were compared with those obtained in another group of five single-kidney hypertensive rabbits submitted to the same protocol but not treated with indomethacin. The blockade of prostaglandin synthesis with indomethacin prevented the increments in renal blood flow and glomerular filtration rate seen in the control rabbits after unclipping a significantly retarded the appearance of diuresis and the fall in blood pressure. Despite these observations, the results do not indicate a major participation ...Continue Reading

References

Mar 1, 1975·Kidney International·V E TorresD M Wilson
Nov 25, 1974·Prostaglandins·V E TorresV R Walker
Oct 1, 1973·The American Journal of Physiology·J C RomeroR J Warzynski
Feb 1, 1972·Acta Physiologica Scandinavica·E AnggårdA B Maunsbach
Jun 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·J C RomeroS W Hoobler
Oct 1, 1967·The American Journal of Physiology·H H JohnstonD P Lauler
May 21, 1934·The Journal of Physiology·R T Grant, P Rothschild

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Citations

May 1, 1977·European Journal of Pharmacology·E OliwB B Fredholm
Jan 1, 1978·Klinische Wochenschrift·R DietzW Rascher
Dec 1, 1975·Circulation Research·L T SkeggsK E Lentz

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