Role of prostanoids in the increased vascular responsiveness and delayed tachyphylaxis to serotonin in the kidney of spontaneously hypertensive rats

Journal of Hypertension
M Tuncer, P M Vanhoutte


The isolated and perfused kidney of the spontaneously hypertensive rat (SHR) exhibits an increased vascular reactivity and a delayed tachyphylaxis to serotonin (5-hydroxytryptamine) when compared with normotensive Wistar-Kyoto (WKY) rats. Experiments were designed to determine the involvement of products of cyclooxygenase in the augmented response and delayed tachyphylaxis to serotonin in the SHR kidney. Kidneys taken from male, 4-month-old SHR and WKY rats were studied in parallel and perfused with Tyrode's solution at constant, optimal flow rates. Vasoconstrictor responses were recorded as increases in perfusion pressure. The vasoconstrictor responses to serotonin, norepinephrine and angiotensin II were exaggerated in the SHR kidney compared with that of the WKY rat. Indomethacin did not affect the responsiveness to serotonin in the kidney of the SHR but increased the responses to the higher doses of the monoamine in the kidney of the WKY rats. Indomethacin accelerated the tachyphylaxis to serotonin in the SHR but delayed it in the WKY rats. Dazoxiben did not alter the responses to serotonin in the SHR. Responses to norepinephrine in the kidneys from both strains were not affected by indomethacin. The inhibitor of cyclooxygen...Continue Reading


Aug 29, 1996·European Journal of Pharmacology·N K FarinaR E Widdop
Oct 1, 1993·Clinical and Experimental Pharmacology & Physiology·B L ZhangJ Sassard
Feb 1, 1993·Kidney International·K EndlichM Steinhausen
Oct 31, 1998·Journal of Hypertension·A Sánchez-MendozaB Escalante

Related Concepts

Angiotensin II, Val(5)-
Eicosatetraenoic Acids
Dose-Response Relationship, Drug
Hypertensive Disease
Norepinephrine, (+, -)-Isomer
Rats, Inbred SHR

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