PMID: 7513530Jan 1, 1994Paper

Role of prostate-specific antigen as a predictor of outcome in prostate cancer

The Prostate. Supplement
G R Blackledge, K Lowery

Abstract

Prostate-specific antigen (PSA) has been shown over the past few years to be a useful and sensitive marker for prostate cancer. During Phase III studies of the nonsteroidal antiandrogen, Casodex, in which different doses were compared with castration (either surgical or medical), serum PSA was measured on a regular basis. Attention was focused on the change in serum PSA from baseline after 3 months Casodex treatment and also on the number of patients receiving Casodex whose PSA returned to the normal range. Data from trials comparing Casodex, 50 mg/day, with castration showed a clear shortfall for Casodex compared with castration, in terms of percentage fall in PSA at 3 months, and also in the number of patients whose PSA fell into the normal range after 3 months. Subsequent analysis showed, however, that the PSA level was related to outcome in terms of time to progression. These data allowed the use of PSA to determine dose selection in a subsequent trial comparing Casodex, 100 mg/day or 150 mg/day, with castration. At the time of dose selection, changes in PSA showed a statistically significant difference between Casodex, 100 mg/day, and castration, but no significant difference between Casodex, 150 mg/day, and castration, ei...Continue Reading

References

Aug 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G L Andriole

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Citations

Jun 1, 1997·The Prostate·X GaoK V Honn
Apr 30, 1999·The Prostate·G J Kolvenbag, A Nash
Feb 14, 2007·Nature Clinical Practice. Urology·Matthew D Galsky, William Kevin Kelly
Feb 1, 1997·American Journal of Clinical Oncology·H GoethuysZ Petrovich
Jun 9, 2005·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Isao KiriyamaTaiji Nishimura
Oct 29, 2004·Clinical Pharmacokinetics·Ian D Cockshott
Dec 11, 1995·International Journal of Cancer. Journal International Du Cancer·E YoshidaH Mihara
Jun 15, 1999·BJU International·J P Van Brussel, G H Mickisch
May 25, 2002·Scandinavian Journal of Urology and Nephrology·G SandblomE Varenhorst

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