PMID: 7539562Jun 1, 1995Paper

Role of prostate-specific antigen density after applying age-specific prostate-specific antigen reference ranges

Urology
A W MeshrefM M Elhilali

Abstract

To determine the potential role of prostate-specific antigen (PSA) density (PSAD) in the early detection of prostate carcinoma if we apply age-specific PSA reference ranges (2.5 ng/mL or less for ages 40 to 49 years, 3.5 or less for ages 50 to 59, 4.5 or less for ages 60 to 69, and 6.5 or less for ages 70 to 79. We retrospectively reviewed 3234 cases referred to us by urologists for transrectal ultrasound (TRUS) between January 1, 1991, and September 28, 1993. We included 2429 patients in the study, ages 40 to 79 years, with Hybritech or Abbott IMx serum PSA determinations and without previously diagnosed prostate cancer. We performed digital rectal examination (DRE) and TRUS in all cases, and TRUS-guided biopsies when indicated. We used stringent criteria to define 736 cases without clinical evidence of malignancy that were designated as a "benign group." In the benign group, we found serum PSA to increase with age in parallel with the increase in prostate volume with age (r = 0.25 and r = 0.26, respectively). The association between serum PSA and prostate volume was stronger (r = 0.46). Using multiple regression analysis, prostate volume accounted for 18% of the variation in serum PSA, whereas age accounted for only an additi...Continue Reading

Citations

May 29, 2002·Urology·Stephen D MikolajczykHarry G Rittenhouse
May 23, 2002·Journal of Computer Assisted Tomography·Ullrich G Mueller-LisseMaximilian F Reiser
Aug 5, 2000·Current Opinion in Urology·M R Feneley, A W Partin
Jul 2, 1998·The Journal of Urology·J G BorerR J Macchia
May 1, 1997·The Urologic Clinics of North America·M C Beduschi, J E Oesterling
Nov 12, 2002·Clinics in Geriatric Medicine·Lodovico Balducci, Claudia Beghé
Nov 20, 1997·The Prostate·B StandaertL Denis
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R K NamS A Narod

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