Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus

Journal of Virology
Einat DeutschRonit Sarid

Abstract

TPA (12-O-tetradecanoylphorbol-13-acetate), a well-known activator of protein kinase C (PKC), can experimentally induce reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) in certain latently infected cells. We selectively blocked the activity of PKC isoforms by using GF 109203X or rottlerin and demonstrated that this inhibition largely decreased lytic KSHV reactivation by TPA. Translocation of the PKCdelta isoform was evident shortly after TPA stimulation. Overexpression of the dominant-negative PKCdelta mutant supported an essential role for the PKCdelta isoform in virus reactivation, yet overexpression of PKCdelta alone was not sufficient to induce lytic reactivation of KSHV, suggesting that additional signaling molecules participate in this pathway.

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Citations

Jul 23, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Shaoying LeeRen Sun
Jun 1, 2011·Advances in Virology·Fengchun YeShou-Jiang Gao
Aug 17, 2005·Cancer Research·Hana OkhrimenkoChaya Brodie
Jan 17, 2015·Viruses·Pravinkumar PurushothamanSubhash C Verma
Oct 19, 2006·Journal of Theoretical Biology·G M KeplerH T Banks
Jun 9, 2005·Critical Reviews in Clinical Laboratory Sciences·Adina CohenRonit Sarid
Mar 18, 2020·Frontiers in Cell and Developmental Biology·Tiziana VescovoManuela Antonioli
Apr 11, 2006·The Journal of General Virology·Patrick W FordShaw M Akula

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