Abstract
Proteins of the macroglobulin family are an ancient and evolutionarily conservative link of the immune system, which is actively involved in both inhibition of tumor growth cells and proliferation of tumor cells. Two basically different binding sites and a great conformational plasticity of all representatives of the macroglobulin family, as well as the presence of two to four representatives of the family in the blood of most species allow them to transport diverse substances and exert various regulatory influences on both the tumor and the entire organism. For example, the capacity of macroglobulins for binding hydrolases makes it possible to inhibit enzyme mediated tumor invasion. At the same time, an excess of macroglobulin/hydrolase complexes can activate apoptosis. The tumor is able of using macroglobulins, especially pregnancy-associated proteins, for its own protection. Specifically, pregnancy-associated alpha2-glycoprotein, which is actively produced by human tumor cells, blocks the histocompatibility complex antigens. On the contrary, the capacity of binding zinc stimulates the thymulin-dependent activation of natural killer cells. Nevertheless, the actively growing tumor expresses many receptors to macroglobulins, wh...Continue Reading
References
Mar 1, 1996·The Journal of Urology·J LeinonenU H Stenman
May 16, 1996·International Journal of Cancer. Journal International Du Cancer·L ChristensenP A Andreasen
Mar 1, 1996·The Journal of Clinical Investigation·G C HowardS V Pizzo
Feb 1, 1996·Molecular Endocrinology·M DajeeJ S Richards
Jun 1, 1996·Immunopharmacology·H MaedaY Sakata
Sep 1, 1996·Virchows Archiv : an International Journal of Pathology·C Piérard-FranchimontG E Piérard
Jan 1, 1997·Cancer Letters·Y LiP K Donnelly
Nov 21, 1997·Biochemical and Biophysical Research Communications·Y LiP Donnelly
Dec 31, 1997·Annals of Surgery·M M HeissF W Schildberg
Feb 7, 1998·The Journal of Biological Chemistry·B P MariM A Shipp
Apr 29, 1998·Journal of Immunotherapy·N L HarthunC L Slingluff
Jan 8, 1999·Brain Tumor Pathology·M YamamotoM Tomonaga
Feb 27, 1999·Haemostasis·M Z WojtukiewiczM Galar
Jan 15, 1999·Glia·I M HussainiS R Vandenberg
Jan 15, 1999·British Journal of Cancer·E MocchegianiG G Garzetti
Jul 30, 1999·Developmental and Comparative Immunology·P B Armstrong, J P Quigley
Sep 24, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L IsaacL M Singer
Oct 21, 1999·Biochemistry·S M Wu, S V Pizzo
Mar 25, 2000·Clinical Science·A Gouin-CharnetA Argilés
Aug 5, 2000·Neurobiology of Aging·T KimparaY Itoyama
Sep 28, 2000·Molecular Human Reproduction·C FocaG E Rice
Dec 10, 2000·The Journal of Biological Chemistry·Y IkariS M Schwartz
Nov 30, 2000·Archives of Biochemistry and Biophysics·I R AsplinS V Pizzo
Dec 6, 2000·Protein Science : a Publication of the Protein Society·D J WebbS L Gonias
Sep 20, 2001·Cancer Chemotherapy and Pharmacology·L DesserI Herbacek
Oct 24, 2001·Vaccine·G J CiancioloS V Pizzo
Dec 26, 2001·The Journal of Biological Chemistry·Uma Kant Misra, Salvatore Vincent Pizzo
Feb 28, 2002·Blood·Martin LinAndre C Schuh
Apr 5, 2002·Molecular Reproduction and Development·Chang-Kyu Lee, Jorge A Piedrahita
May 16, 2002·Vaccine·Hua Xin LiaoBarton F Haynes
Jul 12, 2002·American Journal of Physiology. Renal Physiology·Thomas LudwigStefan W Schneider
Sep 19, 2002·Journal of Neuroscience Research·Gustavo A ChiabrandoPeter H Koo
Citations
Oct 1, 2008·Indian Journal of Clinical Biochemistry : IJCB·Maya RocheK Nalini
Aug 13, 2013·PloS One·Chun-yu HuangJian-chuan Xia
May 26, 2012·Journal of Translational Medicine·Yan HuangJing-Ping Yun
Feb 24, 2016·Cancer Letters·Ming-Yi XuLun-Gen Lu
Sep 26, 2009·Neuroscience and Behavioral Physiology·T V Chernigovskaya