PMID: 7021501Jun 1, 1981Paper

Role of pulmonary edema in the acute pulmonary response to sepsis

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
D R McCaffreeR M Rogers

Abstract

There is evidence that both bronchoconstriction and accumulation of lung water may contribute to the early alterations in lung function following septicemia. Eigher of these may be mediated by blood components. To assess these proposed mechanisms the changes in hemodynamics, pulmonary mechanics, gas exchange, and gravimetric lung water were measured in the first 4 h after Escherichia coli infusion in the anesthetized dog and baboon. These species were selected because of previously demonstrated differences in the response to gram-negative sepsis. Both species developed systemic hypotension and early hypoxemia. The dogs had early transient increases in venous admixture (Qva/Qt) but not shunt or dead space, while the baboon had a more persistent increase in Qva/Qt and a late increase in dead space, Increases in nonelastic resistance and decreases in lung compliance were preceded or accompanied by decreases in the leukocyte count in both species, but the platelet count, fibrinogen, and total hemolytic complement had different changes in the two species. Postmortem lung analysis revealed increased lung weight in both species but the wet weight-to-dry weight ratio was not increased in either species. The fractional water content of ...Continue Reading

Citations

Feb 3, 2007·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Rodrigo Storck CarvalhoPaulo Tavares
Jan 1, 1988·Molecular Aspects of Medicine·N C OlsonC E McCall

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