PMID: 8889315Sep 1, 1996

Role of pulmonary vascular disorder in determining exercise capacity in patients with severe chronic obstructive pulmonary disease

Clinical Physiology
T FujiiJ Yoshikawa


In patients with chronic obstructive pulmonary disease (COPD), the primary cardiovascular complication is the development of pulmonary hypertension, especially during exercise. The purpose of this study was to determine whether pulmonary vascular disorder plays an important role in determining exercise capacity in patients with severe COPD. Twenty-one male patients with severe COPD (mean FEV1 = 0.91 +/- 0.26 1) performed a progressive incremental exercise test, until symptom-limited maximum, to determine maximal exercise capacity, and then a constant-load exercise test for 5 min at a workload (20-60 W) corresponding to 60% of maximal workload during right heart catheterization to characterize the haemodynamic behavior of pulmonary circulation during exercise. The severity of the pulmonary vascular disorder was assessed using the slope of the mean pulmonary arterial pressure (PAP) - cardiac index (CI) relationship during constant-load exercise (P-Q slope). A significant inverse correlation was found between the maximal oxygen consumption (VO2max) and P-Q slope (r = -0.669), but not between VO2max and indices of expiratory airflow obstruction. In addition, the P-Q slope was inversely correlated with mixed venous oxygen tension (P...Continue Reading


Aug 1, 1992·The American Review of Respiratory Disease·J DucasR M Prewitt
Dec 1, 1988·Medicine and Science in Sports and Exercise·D A Mahler, A Harver
Jun 1, 1987·Journal of the American College of Cardiology·D A MorrisonM I Schwarz
Jan 1, 1985·The American Journal of Cardiology·M McGregor, A Sniderman
Sep 1, 1971·American Heart Journal·F Khaja, J O Parker
Apr 27, 1972·The New England Journal of Medicine·B BurrowsC F Diener
Jul 1, 1968·Journal of Applied Physiology·H Levison, R M Cherniack
Jul 1, 1969·The American Journal of Medicine·N O Fowler


Apr 25, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·A C KriegerS Kesten
Jan 6, 2009·Wiener klinische Wochenschrift·Karin VonbankPaul Haber
May 4, 2004·The Annals of Pharmacotherapy·Stacey L Anderson, Scott T Shreve
May 22, 2008·Scandinavian Journal of Medicine & Science in Sports·I VogiatzisS Zakynthinos

Related Concepts

Cardiopulmonary Exercise Test
Pulmonary Hypertension
Lung Diseases, Obstructive
Oxygen Consumption
Pulmonary Circulation
Respiratory Function Tests
Exercise, Isometric

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.