PMID: 8889315Sep 1, 1996

Role of pulmonary vascular disorder in determining exercise capacity in patients with severe chronic obstructive pulmonary disease

Clinical Physiology
T FujiiJ Yoshikawa

Abstract

In patients with chronic obstructive pulmonary disease (COPD), the primary cardiovascular complication is the development of pulmonary hypertension, especially during exercise. The purpose of this study was to determine whether pulmonary vascular disorder plays an important role in determining exercise capacity in patients with severe COPD. Twenty-one male patients with severe COPD (mean FEV1 = 0.91 +/- 0.26 1) performed a progressive incremental exercise test, until symptom-limited maximum, to determine maximal exercise capacity, and then a constant-load exercise test for 5 min at a workload (20-60 W) corresponding to 60% of maximal workload during right heart catheterization to characterize the haemodynamic behavior of pulmonary circulation during exercise. The severity of the pulmonary vascular disorder was assessed using the slope of the mean pulmonary arterial pressure (PAP) - cardiac index (CI) relationship during constant-load exercise (P-Q slope). A significant inverse correlation was found between the maximal oxygen consumption (VO2max) and P-Q slope (r = -0.669), but not between VO2max and indices of expiratory airflow obstruction. In addition, the P-Q slope was inversely correlated with mixed venous oxygen tension (P...Continue Reading

References

Aug 1, 1992·The American Review of Respiratory Disease·J DucasR M Prewitt
Dec 1, 1988·Medicine and Science in Sports and Exercise·D A Mahler, A Harver
Jun 1, 1987·Journal of the American College of Cardiology·D A MorrisonM I Schwarz
Jan 1, 1985·The American Journal of Cardiology·M McGregor, A Sniderman
Sep 1, 1971·American Heart Journal·F Khaja, J O Parker
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Jul 1, 1968·Journal of Applied Physiology·H Levison, R M Cherniack
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Citations

Apr 25, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·A C KriegerS Kesten
Jan 6, 2009·Wiener klinische Wochenschrift·Karin VonbankPaul Haber
May 4, 2004·The Annals of Pharmacotherapy·Stacey L Anderson, Scott T Shreve
May 22, 2008·Scandinavian Journal of Medicine & Science in Sports·I VogiatzisS Zakynthinos

Related Concepts

Cardiopulmonary Exercise Test
Pulmonary Hypertension
Lung Diseases, Obstructive
Oxygen Consumption
Pulmonary Circulation
Respiratory Function Tests
Exercise, Isometric

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