Role of purinergic cotransmission in the sympathetic control of arterial pressure variability in conscious rats

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Léa EmonnotClaude Julien

Abstract

Previous studies have shown that the sympathetically mediated oscillations of arterial pressure (AP), the so-called Mayer waves, are shifted from 0.4 to 0.6 Hz after acute alpha-adrenoceptor blockade in conscious rats. This raises the possibility that, under physiological conditions, Mayer waves are mediated by the conjoint action of norepinephrine and other sympathetic cotransmitters. To evaluate the possible role of the cotransmitter ATP in determining the frequency of Mayer waves, AP and renal sympathetic nerve activity (RSNA) were simultaneously recorded in 10 conscious rats with cardiac autonomic blockade before and after acute blockade of P2 receptors with pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid. P2 receptor blockade did not alter the mean level and overall variability of AP and RSNA but shifted peak coherence between AP and RSNA from 0.43 +/- 0.02 to 0.22 +/- 0.01 Hz. A model of the sympathetic limb of the arterial baroreceptor reflex was designed to simulate Mayer waves at 0.2 and 0.6 Hz, with norepinephrine and ATP, respectively, acting as the sole sympathetic cotransmitter. When both cotransmitters acted in concert, a single oscillation was observed at 0.4 Hz when the gain ratio of the adrenergic to the ...Continue Reading

References

Jul 1, 1995·The American Journal of Physiology·B J JanssenH A Struijker-Boudier
Nov 1, 1994·The American Journal of Physiology·D R BrownD C Randall
Oct 24, 1998·Clinical and Experimental Pharmacology & Physiology·R LétienneC Barrès
May 20, 1999·The Journal of Physiology·W H CookeD L Eckberg
Jun 28, 2000·Journal of the Autonomic Nervous System·V Ralevic
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D BertramC Julien
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J V Ringwood, S C Malpas
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·C D JohnsonJ M Marshall
Dec 26, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·Raj KishoreLaura E Nagy
Mar 21, 2002·Clinical and Experimental Pharmacology & Physiology·C BarrèsC Julien
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaKenji Sunagawa
Feb 1, 2003·Acta Physiologica Scandinavica·O TarasovaH Nilsson
Mar 20, 2003·American Journal of Physiology. Endocrinology and Metabolism·Kazuhiro EtoTakashi Kadowaki
Jun 14, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Claude JulienChristian Barrès
Oct 14, 2003·BMC Physiology·Tom A KuuselaMika Kähönen
Jul 6, 2004·The Journal of Physiology·Bruno ChapuisClaude Julien
Feb 19, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter E Hammer, J Philip Saul
Jun 4, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Delphine BertramClaude Julien
Jun 7, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Atsunori KamiyaMasaru Sugimachi
Dec 20, 2005·Cardiovascular Research·Claude Julien

❮ Previous
Next ❯

Citations

Apr 5, 2016·Journal of Cellular Biochemistry·Alvin M ShihOk-Ho Shin
Mar 1, 2008·Clinical and Experimental Pharmacology & Physiology·Claude Julien
Jun 8, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Adrian GerickeAndreas Patzak
Dec 23, 2019·Cardiovascular Research·Claude Julien
Feb 8, 2019·Frontiers in Neural Circuits·Erik SvenssonHelgi B Schiöth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Related Papers

Clinical and Experimental Pharmacology & Physiology
C BarresClaude Julien
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
D BertramClaude Julien
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Claude JulienC Barres
© 2021 Meta ULC. All rights reserved