Role of putative virulence traits of Campylobacter jejuni in regulating differential host immune responses

The Journal of Microbiology
Ankita Singh, Amirul Islam Mallick

Abstract

Among the major enteric pathogens, Campylobacter jejuni is considered an important source of diarrheal illness in humans. In contrast to the acute gastroenteritis in humans, C. jejuni exhibits prolonged cecal colonization at a high level with little or no pathology in chickens. Although several known virulence determinants of C. jejuni have been found to be associated with a higher degree of pathogenesis in humans, to date, little is known about their functions in the persistent colonization of chickens. The present study was undertaken to assess the role of C. jejuni in imparting differential host immune responses in human and chicken cells. Based on the abundance of major genes encoding virulence factors (GEVFs), we used a particular isolate that harbors the cadF, flaA, peb1, racR, ciaB, cdtB, and hcp genes. This study showed that hypervirulent C. jejuni isolate that encodes a functional type VI secretion system (T6SS) has a greater ability to invade and create characteristic "attaching and effacing" lesions in human INT407 compared to primary chicken embryo intestinal cells (CEICs). Furthermore, we demonstrated that the higher bacterial invasion in human INT407 triggered higher levels of expression of major proinflammatory c...Continue Reading

References

Oct 1, 1988·Applied and Environmental Microbiology·J T BeeryM P Doyle
Apr 1, 1996·The Pediatric Infectious Disease Journal·R P ReedM Khoosal
Nov 21, 1997·Emerging Infectious Diseases·R V Tauxe
Mar 19, 1999·Emerging Infectious Diseases·S F AltekruseD L Swerdlow
Apr 3, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B M Allos
Apr 6, 2002·Rheumatology·T HannuM Leirisalo-Repo
Sep 11, 2002·Cytokine & Growth Factor Reviews·Katsuhiko Ishihara, Toshio Hirano
Nov 19, 2002·FEMS Microbiology Letters·Tracey A BurnettSteven P Djordjevic
Apr 1, 2003·Animal Health Research Reviews·Orhan SahinQijing Zhang
Aug 7, 2003·Applied and Environmental Microbiology·D G Newell, C Fearnley
Mar 24, 2005·Infection and Immunity·Chris K SmithMichael A Jones
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefan PukatzkiJohn J Mekalanos
Sep 26, 2006·Veterinary Immunology and Immunopathology·Yeong Ho HongErik P Lillehoj
Jun 9, 2007·Molecular Microbiology·Mark A SchellDavid Deshazer
Dec 18, 2007·Epidemiology and Infection·L Verhoeff-BakkenesR De Jonge
Mar 12, 2008·Infection and Immunity·Mehmet A EskanDenis F Kinane
May 21, 2008·Cellular Microbiology·Zhongming GeJames G Fox
Sep 5, 2008·Foodborne Pathogens and Disease·Elizabeth AilesElaine Scallan
Jan 14, 2009·Infection and Immunity·Lorna M FriisDiane E Taylor
Aug 12, 2009·International Journal of Medical Microbiology : IJMM·Javid I DastiUwe Gross
Feb 9, 2010·Applied and Environmental Microbiology·Mark ReuterArnoud H M van Vliet
Jul 20, 2010·Cell Host & Microbe·Andrea J Jani, Peggy A Cotter
Jul 20, 2010·Applied and Environmental Microbiology·Friederike HilbertMichael P Szostak
Jul 1, 2011·Veterinary Research·David HermansFrank Pasmans
Sep 6, 2011·Journal of Bacteriology·Sarah L MurdochSarah J Coulthurst
Dec 3, 2011·Vector Borne and Zoonotic Diseases·David HermansFreddy Haesebrouck
Aug 25, 2012·Frontiers in Cellular and Infection Microbiology·Abofu AlemkaBilly Bourke
May 27, 2014·Emerging Infectious Diseases·James W HarrisonOlivia L Champion

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