Jul 1, 1977

Role of quaternary structure in the antigenic specificity of amino acid derivatives of hemoglobin

Voprosy medit︠s︡inskoĭ khimii
A A Levina, A P Andreeva


Immunochemical properties of isolated alpha- and beta-chains of aminoenanthyl- and phenylalanyl-hemoglobins were studied by fixation of the complement as compared with the corresponding chains of the native hemoglobin. In spite of the immunochemical differences between Phe-Hb and hemoglobin, the complement fixation ability was shown to be the same in Phe-Hb, AE-Hb and hemoglobin; this phenomenon suggests that formation of the antigenic determinant in Phe-Hb occurs at the level of quaternary structure.

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Amino acid derivative
Antigenic Specificity
Sample Fixation
Hemoglobin Measurement
Observation Method - Complement Fixation

About this Paper

Related Feeds

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.