Jul 1, 1977

Role of quaternary structure in the antigenic specificity of amino acid derivatives of hemoglobin

Voprosy medit︠s︡inskoĭ khimii
A A Levina, A P Andreeva

Abstract

Immunochemical properties of isolated alpha- and beta-chains of aminoenanthyl- and phenylalanyl-hemoglobins were studied by fixation of the complement as compared with the corresponding chains of the native hemoglobin. In spite of the immunochemical differences between Phe-Hb and hemoglobin, the complement fixation ability was shown to be the same in Phe-Hb, AE-Hb and hemoglobin; this phenomenon suggests that formation of the antigenic determinant in Phe-Hb occurs at the level of quaternary structure.

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Mentioned in this Paper

Amino acid derivative
Antigenic Specificity
Sample Fixation
Chinchilla<genus>
Hemoglobin Measurement
Eryhem
Observation Method - Complement Fixation
Hemoglobin
FARSB
Epitopes

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