Role of Radiation Therapy in the Treatment of Hodgkin Lymphoma

Current Hematologic Malignancy Reports
Victor J Gonzalez

Abstract

Radiation therapy has historically been the pillar of curative treatment for Hodgkin lymphoma (HL). With improved efficacy of systemic therapy and the ever-increasing recognition of treatment-related morbidity in long-term survivors, the role of radiotherapy has evolved significantly. Modern combined modality therapy (CMT) with multi-agent chemotherapy followed by involved site radiation therapy (ISRT) to initially involved sites of disease remains the gold standard for the majority of patients with HL. Reduction of long-term treatment-related toxicity has become the major driver in clinical trial design for early-stage HL while improved disease-specific survival remains the goal in patients with more advanced and unfavorable disease. This review will address the data supporting the use of radiotherapy in HL as well as specific methods for reducing late toxicity from radiotherapy.

References

May 9, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·F ErikssonL E Rutqvist
Apr 17, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrea K NgPeter M Mauch
Jun 13, 2003·The New England Journal of Medicine·Berthe M P AlemanUNKNOWN European Organization for Research and Treatment of Cancer Lymphoma Group
Nov 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew J KrasinMelissa M Hudson
Jun 27, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Theodore GirinskyEvert Noordijk
Feb 8, 2007·Journal of the National Cancer Institute·Anthony J SwerdlowDavid C Linch
Mar 3, 2009·International Journal of Radiation Oncology, Biology, Physics·Sughosh DhakalLouis S Constine
May 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter W M JohnsonSally P Stenning
Aug 18, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans Theodor EichAndreas Engert
Sep 8, 2010·The New England Journal of Medicine·Andreas EngertVolker Diehl
Apr 13, 2011·International Journal of Radiation Oncology, Biology, Physics·Amaury PaumierTheodore Girinsky
Jun 28, 2011·International Journal of Radiation Oncology, Biology, Physics·Amaury PaumierTheodore Girinsky
Dec 14, 2011·The New England Journal of Medicine·Ralph M MeyerUNKNOWN Eastern Cooperative Oncology Group
Jan 19, 2012·International Journal of Radiation Oncology, Biology, Physics·Matthew KoshyYoung Kwok
May 30, 2012·BMC Cancer·Ezzeldin M IbrahimMeteb Al-Foheidi
Dec 4, 2012·International Journal of Radiation Oncology, Biology, Physics·Maja V MaraldoLena Specht
Jun 25, 2013·International Journal of Radiation Oncology, Biology, Physics·Lena SpechtUNKNOWN ILROG
Oct 15, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A E HayUNKNOWN Conducted by the NCIC Clinical Trials Group (Canada) and German Hodgkin Study Group (GHSG)
Dec 30, 2014·International Journal of Radiation Oncology, Biology, Physics·Kavita V DharmarajanSuzanne L Wolden
Mar 11, 2015·International Journal of Radiation Oncology, Biology, Physics·Marianne C AznarPeter M Petersen
Apr 13, 2015·International Journal of Radiation Oncology, Biology, Physics·Jan KrizHans Theodor Eich
Apr 23, 2015·The New England Journal of Medicine·John RadfordSally Barrington
Aug 19, 2015·International Journal of Radiation Oncology, Biology, Physics·Rahul R ParikhJoachim Yahalom
Nov 18, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frederika A van NimwegenFlora E van Leeuwen
Dec 25, 2015·The New England Journal of Medicine·Michael SchaapveldFlora E van Leeuwen
Mar 15, 2016·International Journal of Radiation Oncology, Biology, Physics·Peter D InskipJoseph P Neglia
Dec 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Jessica L ConwayTom Pickles
Mar 16, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc P E AndréJohn Raemaekers

❮ Previous
Next ❯

Citations

Jul 20, 2017·The Journal of Pathology·Pei Chuan LiJean Chen Shih
Oct 3, 2020·Expert Opinion on Biological Therapy·Samer A Al Hadidi, Hun Ju Lee
Nov 9, 2020·Clinical Lymphoma, Myeloma & Leukemia·Samer A Al-HadidiHun Ju Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Cochrane Database of Systematic Reviews
Christine HerbstAndreas Engert
Annals of Oncology : Official Journal of the European Society for Medical Oncology
S SasseGerman Hodgkin Study Group (GHSG)
Mediterranean Journal of Hematology and Infectious Diseases
Umberto RicardiPierfrancesco Franco
© 2022 Meta ULC. All rights reserved