PMID: 8946029Nov 4, 1996Paper

Role of radioadaptation on radiation-induced thymic lymphoma in mice

Mutation Research
D Bhattacharjee

Abstract

Thymic lymphoma (TL) was observed in different stages of development in 46% of male mice (23/50) following exposure to an acute challenge dose of 2 Gy 60Co gamma-rays. With an adapting dose of 1 cGy 24 h prior to the challenge dose of 2 Gy, similar growth of TL was seen in 42.5% of mice (17/40). TL was not found in unirradiated control mice (0/50) or in the group treated with 1 cGy (0/50). Multiple adapting doses for 5 or 10 consecutive days induced TL in 8/50 and 9/50 mice, respectively (17% in average). When multiple adapting doses were followed by the challenge dose, the yield of TL was much lower, 16% (8/50) and 30% (15/50), respectively. By 15, 30, 60, 90, and 120 days after exposure with 3 Gy of 60Co gamma-rays, TL developed in 30, 70, 70, 80 and 85% of the female mice, respectively. When mice were conditioned with an adapting dose of 1 cGy 24 h prior to the challenge dose, TL was not found 15 days post-irradiation, while about a 25% reduction in the occurrence of TL was noticed at all other intervals. The results suggested that an adapting dose could play a role in bringing about a change in terms of delay and inhibition of the acute effects of radiation, i.e., the onset of TL in mice.

Citations

Nov 26, 2002·International Journal of Cancer. Journal International Du Cancer·Octávia Monteiro GilJosé Rueff
Aug 3, 2004·Journal of Biosciences·Ashu Bhan Tiku, R K Kale
May 30, 1998·Biochemical Pharmacology·C Stecca, G B Gerber
Aug 6, 2002·Mutation Research·Karen J SorensenJames D Tucker
Mar 31, 1998·Environmental Health Perspectives·S Wolff
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·D R BorehamR E J Mitchel
Nov 5, 2013·Antioxidants & Redox Signaling·Aris T Alexandrou, Jian Jian Li
Apr 16, 2013·Antioxidants & Redox Signaling·Demet Candas, Jian Jian Li
Feb 20, 2014·Mutation Research. Reviews in Mutation Research· VijayalaxmiMaria Rosaria Scarfi
Jun 19, 2012·International Journal of Radiation Biology·Irena Szumiel
May 25, 2013·Biochemical and Biophysical Research Communications·Akira OnoderaNorio Itoh
Apr 1, 2017·Cancer Immunology, Immunotherapy : CII·Marek K JaniakEdward J Calabrese
Dec 21, 2007·Environmental and Molecular Mutagenesis·Michael KilemadeDouglas Boreham
May 11, 2011·Expert Review of Anticancer Therapy·Abdullah FarooqueBilikere S Dwarakanath
Dec 29, 2006·Journal of Radiation Research·Akio ShigematsuSusumu Ikehara
Aug 15, 2009·Journal of Radiation Research·Shizuko KakinumaYoshiya Shimada
Jul 12, 2002·Environmental and Molecular Mutagenesis·Vasily N DobrovolskyRobert H Heflich
Jan 26, 2010·Radiation Research·Benjamin J BlythPamela J Sykes
Oct 31, 2007·Free Radical Biology & Medicine·Kazi Mokim Ahmed, Jian Jian Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.