Role of rapid on-site evaluation with cyto-histopathological correlation in diagnosis of lung lesion

Journal of Cytology
Smita ChandraGirish Sindhwani

Abstract

This study was conducted to assess the role of cytology in the diagnosis of lung lesions and to compare it with histopathology. It was also intended to evaluate the role of rapid on site evaluation (ROSE) as an adjunct to cytological diagnosis of lung lesions. The study included all the cases of lung lesions, which were diagnosed on cytology followed by histopathology over a period of 2½ years along with ROSE, wherever possible. Cytology was done in total 782 cases of various lung lesions and of this cyto-histopathological correlation was available in 215 cases. ROSE was done in 93.4% of total cases and smears were considered on the site adequate in the first pass in 68.1% cases and in second pass adequacy increased to 93.4%. The diagnostic accuracy of cytology was 75.3%, and that of histology was 86.9% in the diagnosis of lung lesions. The diagnostic accuracy of cytology for squamous cell carcinoma (94.4%) and adenocarcinoma (96.5%) was higher than that of histology. Cytology is comparable to histology in the diagnosis of lung lesions and may even outperform biopsy in lung tumor diagnosis. The advantages of cytology may be further added by better sampling and preanalytical assessment for adequate diagnostic material and ROSE h...Continue Reading

Citations

Jun 9, 2020·Cytopathology : Official Journal of the British Society for Clinical Cytology·Keluo Yao, Zaibo Li
Jun 26, 2020·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Caili LiJing Feng
Jul 18, 2018·BMC Research Notes·Piyumali Sandareka ArachchiChinthika Prabhashinie Gunasekara
Mar 17, 2018·Journal of the American Society of Cytopathology : JASC·Oscar Lin
Oct 31, 2020·Journal of Bronchology & Interventional Pulmonology·Richa GuptaPrince James

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Methods Mentioned

BETA
biopsies
lavage
biopsy

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